Cascara Sagrada, Rhamnus purshiana.. This is a bitter tonic influencing to healthy action the gastro-intes-tinal tract, promoting the secretions of their glands, and increasing peristalsis. It is a valuable agent, but is of use chiefly in chronic constipation. Give of the fluidextract from 5 to 60 TTL. It has been commended in chronic rheumatic states and used in quite small doses, but has hardly justified itself in this connection.