This section is from the book "An Experimental History Of The Materia Medica", by William Lewis.
Conessi Med. ess. Edinb. Codago-pala Hort. malabar. Ph. Paris. Conessi: the bark of a small tree, (Nerium antidysentericum Linn.) growing in the island Ceylon and Malabar; of a dark blackish colour on the outside, covered more or less with a white moss or scurf: the bark of the small young branches, which has the least of this matter, is preserved. It has but lately been introduced into Europe, and is as yet little known in the shops.
This bark, to the taste gratefully austere and bitter, is recommended in the Hortus Mala-baricus for the cure of diarrhoeas; and its efficacy in this disorder has been confirmed in the Edinburgh medical essays. The bark, freed from the scurf, is directed to be made into an electuary with syrup of oranges, and taken to the quantity of half a dram or more four times a day: it sensibly loses of its roughness and its virtue if kept for two or three days, in the form either of powder or electuary; and hence fresh quantities are to be prepared at least every other day. It is said, that the first day of taking the medicine, it increases the number and quantity of of the stools, without increasing the gripes; that on the second day, the colour of the stools is mended; and that on the third or fourth day, if it succeeds at all, the consistence generally comes near to a natural state: that in recent diarrhoeas, from irregularities, it seldom fails to cure, if a vomit, of ipecacoanha, is given immediately before its use: that the same management succeeds in persons of a lax habit, to whom diarrhoeae are familiar in moid weather: but that, in any case, if a fever is joined, the coneffi has no place till the fever is removed, Mr. Monro informs us, in the Essays above-mentioned, that he cured a dysentery of three years standing, which had refilled a great variety of other medicines, by giving this bark in the form above prescribed.
Tinct. Co-lombae Ph. Lond.