This method differs from the enepidermatic in that friction is employed to promote absorption by forcing the medicament between the cells of the epidermatic layer. Many agents are used in this way, as mercurial ointment in syphilis, cod-liver oil, and other fats, in wasting diseases, and ointments of various kinds for the relief of local lesions, etc. The evidence is conclusive that by this mode systemic effects are produced.