In preparing this edition I have corrected some typographical and other errors, and have added various new articles which will, I hope, improve the interest and value of the work. In this, as in all previous issues, the practical character of the work as a storehouse of facts relating to Muter Medica and Therapeutics has been preserved.

I have not been unmindful of the present tendency of pharmacological literature. An increasing disposition is discernible to develop the physiological side, to enlarge the domain of experimental work, and to interpret conditions in man by hasty and sometimes crude observations on the inferior animals. On the other hand, empirical knowledge, supported by careful clinical work, and improved by sound induction, should continue to be an important element in the structure of any therapeutically system.

I have again to thank my readers and constant friends for their approval of the successive issues of my Treatise.

R. B.

Philadelphia, Pa., 1903.