Tremor. An interesting and unusual manifestation of urine intoxication is reported by Hock (43) in which intense tremor of the entire body, such as is occasionally observed in ether intoxication, was caused by partial retention of urine in the bladder, and this disappeared after complete emptying of the bladder. From his observations it seems that suppression or complete retention of the urine is not necessary to cause urine intoxication, and that severe diarrheas, rebellious vomiting and uncontrollable disturbances of the gastrointestinal tract may be removed by treating the urinary condition. He also attributes the singultus accompanying cystitis to the absorption of urine and resulting systemic poisoning. In this connection the occurrence of uncontrollable diarrheas in the pathogenesis of urea may be cited.