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Auto-intoxication as a Cause and Complication of Disease | by W. Louis Chapman, M. D.



It will be the general plan of this paper to discuss the individual factors of auto-intoxication, their properties and the conditions under which they may be formed, and the diseases into whose etiology they enter, or which they may complicate.

TitleAuto-intoxication as a Cause and Complication of Disease
AuthorW. Louis Chapman, M. D
PublisherProvidence
Year1903
Copyright1903, W. Louis Chapman, M. D
AmazonAuto-intoxication As A Cause And Complication Of Disease
Auto-intoxication as a Cause and Complication of Disease
-Preface To Auto-intoxication as a Cause and Complication of Disease
It will be the general plan of this paper to discuss the individual factors of auto-intoxication, their properties and the conditions under which they may be formed, and the diseases into whose etiolo...
-Part I. Auto-intoxication as a Cause and Complication of Disease
Although all the vital processes which take place in the body are in a great measure co-operative and interdependent, that of metabolism, with its indispensable function of elimination is conspicuous ...
-The Theoretical Biology of the Cyto-Lysins
Besides the better known products of metabolism the properties of which are fairly well understood, there is a class of bodies the functions of which are not so well known, the study of which is now e...
-Part II. The Individual Factors of Auto-intoxication - The Urine as Concerned in Auto-intoxication
The idea that the urine is distinctly poisonous is not a new one. For a long time it has been known that it contained poisons castoff from the system, that toxic symptoms ensued if it was consumed by ...
-The Urine And Auto-intoxication
The experimental study of the urine as a toxic factor consists in the administration to animals of the urine and the several substances which compose it. If injected subcutaneously we find that it act...
-The Urinary Components
Urea is the amid of carbonic acid, best represented by the constitution formula: It is neutral in its reaction, readily soluble in water, and when administered is excreted unchanged and as ammonium...
-The Urinary Components. Part 2
Indol although it exists in small amount in normal urine is formed particularly by the bacterial decomposition of proteids in the intestine. Its chief source is tyrosin, one of the cleavage product...
-Auto-toxins of Alimentary Origin
The auto-toxins of intestinal origin comprise by far the greater number of factors which may act as causes and by far the most virulent of the intrinsic poisons. Endeavoring always to exclude poisons ...
-The Bile Acids And Auto-intoxication
The Bile Acids have a powerful cytolitic action and even in small amounts cause widespread disintegration of the red blood corpuscles with liberation of their hemoglobin, and also the disintegration o...
-Ptomaines And Auto-intoxication
Although many of the monamins and diamins are physiologically inactive, and although many of the poisonous ones are the result of the pathogenic bacteria of the specific infectious diseases, there are...
-Ptomaines And Auto-intoxication. Part 2
Cadaverin Cadaverin, C5 H14 N2, is isomeric with saprin and neuridin, and is very commonly met with in decomposing animal tissues. It forms as early as the third day of putrefaction, preceding putres...
-Ptomaines And Auto-intoxication. Part 3
Neurin is a highly toxic substance of obscure genesis. It may be prepared from cholin and is almost always accompanied by it, but the manner in which it is formed in the body is not yet clear. It i...
-Leucomaines And Auto-intoxication
These are basic substances which either exist preformed in the proteid molecule or are produced by tissue metabolism. The leucomaines are cleavage products while the ptomaines are formed by the splitt...
-Leucomaines And Auto-intoxication. Continued
Pyrimidin Bases Of the Pyrimidin bases the di- and tri-amino derivatives are toxic, and these yield insoluble- compounds which may be deposited in the renal tubules. Hexon Bases Of the Hexon base...
-Other Substances acting as Auto-toxins
Butyric Acid Butyric Acid, C4H802, is very commonly produced in gastro-intestinal fermentation, and is most commonly formed by the fermentation of cane sugar. It mixes with water in all proportions a...
-The Poison Of Expired Air
The poison of Expired Air. It is well known that air once breathed is unfit for further respiration, and this change is due to the carbonic oxid it contains and to a peculiar poison caused by tissue w...
-Toxicity Of Auto-toxins Compared With Other Poisons
The following table shows the toxicity of some of the Auto-toxins as compared with that of other poisons: SUBSTANCE. MINIMUM LETHAL DOSE PER K. INVESTIGATOR. Normal Urine 45.00 cc. Bouchard...
-Part III. The Particular Diseases which are caused by Auto-intoxication
Although auto-intoxication may be concerned in any disease and any departure, however small, from normal physiological activity be followed by a corresponding change in the products of metabolism, it ...
-Diseases of the Digestive System
Since the digestive tract is the most common source of intrinsic toxic materials it is natural to suppose that its disorders are very commonly due to these substances. As already stated disorders of t...
-Constipation And Auto-intoxication
Constipation causes self-poisoning chiefly by retaining materials in the digestive tract long enough for absorption to take place, or for poisonous bases to form. It was shown in Part II that putresci...
-Hepatic Disorders And Auto-intoxication
The claim that diseases of the liver and gall bladder produce toxemia is based upon four facts: 1. That bile itself, when absorbed into the system, acts as a poison and produces a definite toxemia. ...
-Jaundice And Auto-intoxication
Jaundice is a disease in which the pathologic changes are unquestionably due to auto-intoxication. The bile, which in a state of health is cast off from the body in the feces, or is resorbed and elimi...
-Hepatic Cirrhosis And Auto-intoxication
Hepatic Cirrhosis has been produced experimentally in animals by the administration of antipyrine, the bacillus coli communis, hyoscyamus, toxalbumins and an exclusive meat diet. (17) This suggests th...
-Nephritis. Its intrinsic origin and its relation to auto-intoxication
The great similarity of the numerous toxic agents described in Part II with the better known poisons warrants one in making analogies which suggest that they too are capable of causing tissue changes,...
-Lithemia and Allied States
A large amount of clinical and experimental data combine in support of the view that the element of acid intoxication is a very important one in the etiology of lithemia, rheumatism, gout and the into...
-Diabetes And Auto-intoxication
Although, many theories as to the cause of diabetes have been offered, the concensus of opinion is that it arises either from irritation of the diabetic centre in the floor of the fourth ventricle, or...
-Autointoxication as a Complication in Pregnancy and the Puerperium
Puerperal Temperatures It is highly probable that many cases of puerperal temperature which have been reported as those of auto-intoxication are in reality unrecognized infections from germ invasion....
-Eclampsia And Auto-intoxication
This disorder has long been considered as a form of auto-intoxication and the theories propounded have been many and varied. Its similarity with uremia has led to the opinion that renal insufficiency ...
-Diseases of the Skin And Auto-intoxication
In the auto-toxic etiology of diseases of the skin two elements are of importance, - the nervous and the vascular. The nervous because the peripheral nerves are everywhere present in the skin, and imp...
-Eczema And Auto-intoxication
That Eczema is the direct result of auto-intoxication appears from its intimate relation with lithemia and gouty states, and from its dependency upon digestive disorders. The eczema and herpes which a...
-Diseases of the Nose and Throat And Auto-intoxication
That acute disorders of the nose and throat are often caused by digestive disturbances is almost universally acknowledged, for clinical experience frequently shows the correlation between these organs...
-Disorders of the Heart And Auto-intoxication
Of the various disorders of the heart, we must recognize palpitation, overaction, delirium cordis, peripheral hyperemia, variations in blood pressure, toxic angina and the manifestations of the rheuma...
-Auto-Intoxication Affecting the Nervous System
Since experimental poisonings with almost all the auto-toxins show their selective affinity for the nervous system it is necessary to discuss more fully these effects and see how they contribute to th...
-Convulsive States And Auto-intoxication
Epilepsy has long been classified as a neurosis without known anatomical basis and although its precise origin has not yet been proven, recent investigation has contributed much information as to the ...
-Tremor And Auto-intoxication
Tremor. An interesting and unusual manifestation of urine intoxication is reported by Hock (43) in which intense tremor of the entire body, such as is occasionally observed in ether intoxication, was ...
-Infantile Convulsions And Auto-intoxication
Infantile Convulsions. Gastro-intestinal disorders are among the most common causes of infantile convulsions, and they act in the ways already explained. The intestinal walls of infants permit the ...
-Gastric Tetany And Auto-intoxication
Gastric Tetany. In the experimental study of the factors which may act as auto-toxins their resemblance to the bacterial toxins is continually in evidence, and the ability of many of these materials t...
-Delirium Tremens And Auto-intoxication
Delirium Tremens. It is very probable that the auto-toxins play an important part in the etiology of delirium tremens. This disease is primarily a toxic state due to alcoholic saturation, but when ren...
-Depressed States And Auto-intoxication
Mental depression is a very common accompaniment or symptom of the absorption of toxic materials of autogenous origin. It occurs in the pathogenesis of many of the substances described in Part II and ...
-Albuminuria And Auto-intoxication
In Albuminuria there is a marked tendency to depression and irritability. Worry and hypochondriasis are frequently due to renal disorders and these may increase to temporary mental aberration with sui...
-Insomnia And Auto-intoxication
Insomnia. Auto-intoxication not only causes mental lassitude, malaise, languor and depression, but also the opposite state, that of insomnia and mental exaltation. The philosophy of this is that the a...
-Narcolepsy And Auto-intoxication
In Narcolepsy we have the very opposite condition to insomnia, in which the patient is seized with a sudden and uncontrollable desire to sleep. Fisher claims that if hysteria, diabetes and nephritis c...
-Insanity And Auto-intoxication
Insanity. All modern investigators acknowledge the importance of autogenous poisons in the etiology of insanity. Hamilton (53) has made a special study of the urine and digestion in the insane and off...
-The Ductless Glands as concerned in Auto-intoxication
At the present state of our knowledge it is difficult to assign to the ductless glands their proper place in the animal economy, or to tell what part they play in the elaboration or neutralization of ...
-References For Auto-intoxication as a Cause and Complication of Disease
1. Lindemann. Ann. de l'Inst. Past. XIV, 1900. 2. Mathieu and Roux. Arch, gen de Med. Jan., 1902. 3. Herter. Jns. Hpk. H. Rpts. IX. 69-109. 4. Zoetber and Ibrahim. Zeits. f. phys. Chem. XXXY, 1. 5...









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