The reports in regard to the physiological action of cocaine differ. In small doses (0.05 to 0.15 g.) it is supposed to act as a stimulant, aid digestion, increase physical strength, suspend sleepiness and hunger, and is recommended against alcoholisms and morphiomany. Cocaine is also a very powerful anaestheticum, and even by application to the skin it causes insensibility for several minutes; it is in no sense intoxicating. The evidence is accumulating that the peculiar effects obtained by the chewers of coca-leaves are due, at least in part, to something besides cocaine (probably hygrine and some other yet unknown constituents). It is certain that the alkaloid - cocaine - does not have the-peculiar sustaining influence attributed to the leaves. That the use of cocaine is not unattended with danger ought to be generally understood. While one physician maintains the harmlessness of the drug, the other asserts the contrary, and claims that it undermines the moral and intellectual qualities. Sufficient facts have not yet been accumulated to serve as a basis for scientific conclusions, but it is plain that cocaine must be ranked with those seductive drugs which enslave.