These terms imply necrosis or loss of tissue, generally of a progressive character.' The loss of tissue may be rapid, and involve the formation of visible sloughs, or it may be gradual, a molecular necrosis, the dead particles being absorbed or removed in the exudation. These results are produced by very intense irritants, and the inflammations are usually of an infective and suppurative character. While ulceration expresses the process of progressive destruction of tissue, the ulcer is the open exposed gap in the tissue. If the ulceration pauses, then the ulcer becomes covered with granulations and is converted into a granulating wound.


John Hunter, A treatise on the blood, inflammation, and gun-shot wounds, 1793; Cohnheim, Allg. Path., vol. i.; Recklinghausen, Allg. Path.; Virchow, Handb. d. spec. Path.u. Therap., vol. i., and Cellular Pathology; Paget, Lect. on. Surg. Path.; Billroth, Entz. d. Blutgefiiss., 1856; Meyer, Charite-annal, iv., 1; Arnold, Virch. Arch., liii., liv.; Thiersch in Pitha-Billroth's Handb., i.; Haukelem, Virch. Arch. cvii.; Yamagiwa, Virch. Arch, cxxxii., 446; Metchni-koff, Comp. Path, of Inflam., trans, by Starling, 1893. State of Vessels - Lister, Phil, trans., 1858, vol. cxlviii.; Saviotti, Virch. Arch., vol. 1.; Cohnheim, Neue Unters. uber d. Entzundung, 1873; Burdon Sanderson, Holmes' Syst. of Surgery, 3rd ed., 1883, vol. i.; Thoma, Virch. Arch., vols. lxii. and lxxiv.; Wharton Jones, The blood and blood-vessels in inflammation, 1853. Temperature - John Hunter, Palmer's ed., ill., 338; Simon, Holmes' Syst. of Surg., vol. i.; Weber, Pitha-Billroth's Handb., i., 381; Jacobson, Virch. Arch., li.; W. Lawrence, Lect. on Surgery, 1863. Exudation - W. Addison, Healthy and diseased structure, 1849; Williams, Principles of med., 1843; Waller, Phil. Mag., 1846, vols, i., ii.; Recklinghausen, Virch. Arch., xxviii., and Strieker's Handb.; Arnold, Virch. Arch., lxxiv.; Goodsir, Edin. Monthly Jour., 1849; Axel Key and Wallis, Virch. Arch., Iv.; Bottcher, Virch. Arch., lxii.; Cohnheim, 1. c. and Allg. Path. 1882; Stkicker, Wien. Med. Jahrb., 1871-83; Ogston, Brit. Med. Jour., 1881, vol. i.; Rosenbach, Wundinfectionskrankheiten, 1883; Weigert, Eulenburg's Encyclop. Art. Entzundung; Grawitz and De Bary, Virch. Arch., cviii. and ex.; Gaylord (fibrinous exudates), Jour. Exper. Path., iii., 1898. New-formation - Ziegler, Inter, uber path. Bindegeweb und Gefiissneubild, 1876; Sherrington and Ballance. Jour, of Anat. and Physiol, x., 1889.