This section is from the book "Research In Physiopathology As Basis Of Guided Chemotherapy With Special Application To Cancer", by Emanuel Revici. Also available from amazon: Research In Physiopathology
We submitted groups of mice grafted with DBA mammary adenocarcinoma, to treatment with various lipoacids or positive lipoids preparations. After ten days of treatment the tumors were removed and analyzed for their content of chlorides, using the Volhard technic, in which the titration of silver nitrate was made electrometrically. As lipoacids, we used for experiment cod liver oil fatty acids, lipoacids from human placenta and butyl mercaptan; for lipids with a positive character, we used cholesterol, insaponifiable fractions of human placenta and butanol. In all cases treated with lipoacids, the amount of chlorides was higher than in untreated controls. With cod liver oil fatty acids, values as high as 135% above those of controls were found. With the lipoacids of human placenta, the average value was 114% above that of controls; with mercaptans, 78% above. The influence exerted by the opposite lipids was much less manifest. With cholesterol and insaponifiable fractions, chloride values were 20% below those of controls; with butanol, 33% below.
We studied the influence exerted by the series of alpha OH fatty acids, saturated and unsaturated, upon the evolution of different tumors in mice and rats, to find that only one member has a manifest effect which is limited to a single tumor. Subcutaneous grafts of 6C3HED lymphosarcoma in C3H mice grew with abnormal rapidity. 48 hours after the transplant, the tumor could be felt. A very soft, highly edematous and, for this reason, diffuse tumor developed rapidly so that death occurred usually around the tenth day. This tumor was especially resistant to most of the chemothera peutic agents tested. Daily administration of a 5% solution of alpha OH caprylic acid in a dose of 0.2-0.5 cc, started even the fifth day after the graft when the tumor was already well developed, was followed by its rapid involution and disappearance in a high proportion of cases (55/60). In the few cases in which the tumor persisted, its evolution was very much changed. The animals remained alive for more than a month. If, after three or four days, when the tumor was already highly reduced, the administration of the preparation was discontinued, the tumor began to grow again, but much more slowly than usual.
Fig. 290. The administration of alpha OH caprylic acid in mice bearing 6C3HED lymphosarcoma tumor, induces the disappearance of the tumor in a high proportion of cases.