Parallel to investigation of agents capable of correcting offbal ances of type A, attention was directed to agents that might influence the opposite offbalance, type D. Since fatty acids are involved in the pathogenesis of type D offbalance, agents with anti fatty acid properties had to be sought as correctives. Some of these are natural constituents used by the body to control normal and abnormal intervention of fatty acids. They were consequently isolated and studied. Synthetic agents also were obtained and studied, their choice largely inspired by the control mechanism used by the body.

Anti Fatty Acids Constituents

We have seen that a free fatty acid loses most of its biological activity when its polar group is bound to another radical. This led us to investigate substances which naturally are bound to fatty acids. It could be shown further that each major group of fatty acids is bound in the organism to specific constituents. The saturated fatty acids are principally bound to glycerol, the low unsaturated acids to glycerophosphoric acids as lecithins, and the high unsaturated members to sterols. The conjugated fatty acids, found in abnormal conditions, appeared to be opposed by neoglucogenic corticoids. The constituents* were conceived of as being naturally occurring anti fatty acid substances and our first effort was to study how they intervene to balance the activity of fatty acids, especially when the latter act as pathogenic factors.

In this study, two types of influences were investigated: one, a relatively direct effect induced through a neutralization of the energetic centers resulting in a more or less advanced degree of inactivation of the fatty acid; the second, an indirect effect achieved through changes in the metabolic processes in which fatty acids intervene. In a different kind of intervention, the anti fatty acid to which a fatty acid is bound governs its ultimate biological fate. For example, the bond to glycerol favors caloric metabolism. The bond to glycerophosphoric ion converts a fatty acid, saturated as well as unsaturated, into an organizational constituent. The bond to sterols favors a functional role, even for monoethenoids.

We started the study of the naturally occurring anti fatty acids with those agents known to be bound to fatty acids in the organism. The simplest such agent is glycerol.