When these are present in large numbers, the face appears as though gun powder had been blown into it, or pepper sprinkled over it. It is best to remove them, as, if not removed, nature undertakes the work by setting up an inflammation about each one and producing real acne. They may be squeezed out by pressure between the nails, but are best removed by a little tube with an opening about the thirty-second of an inch in diameter, or a watch key, which should be pressed directly down upon the affected gland, care being taken not to injure the skin by too great pressure. The further treatment of comedo should be the same as recommended elsewhere for oily skin.