This section is from the book "A Practitioner's Handbook Of Materia Medica And Therapeutics", by Thos. S. Blair. Also available from Amazon: A Practitioner's handbook of Materia Medica and Therapeutics.
Juglans Cinera, Butternut. The inner bark of the root was at one time much employed in medicine, an aqueous extract being used in doses of from I to 5 gr. This remedy is an instance of the therapeutic iconoclasm of to-day. The whole effort is to develop new remedies. From the very dawn of medical science, good old remedies, such as juglans, have been produced by nature and to-day do just the same things as they did for our fore-fathers, only we are forgetting all about them in our foolish haste to have the chemist make for us remedies seldom the equal of those elaborated by nature.
In large doses (f.e., 20 to 30 I.; ec. tr., 20 I; juglandin, I gr) it is cathartic and cholagogue, producing ~ large, bilious motions without griping. It is as gentle as rhubarb, but much more thorough. The extract is made up into pills, and is effective in 5 gr. doses. It is highly useful in malarial fevers in cathartic doses. In moderate doses (extract, I gr; i.e. or ec. tr., 3 to I.) it is a mild laxative, valuable in habitual constipation and the resulting dyspepsia, and exercising a most excellent influence upon the liver.
In small doses (f.e. or ec. tr., 1-3 to I I.) it is indicated in skin diseases induced by gastro-intestinal troubles and faulty elimination, such as eczema, acne, impetigo, pemphigus, and several of the scaly skin diseases. Small doses will also relieve occipital headache associated with hepatic disturbances.