This process is preferable in case of some gums, resins, etc, which are almost entirely soluble.

1. Reduce to a coarse powder, or cut into small pieces, and having ascertained the strength of spirit to be used, put the drug with the whole of the spirit into a wide-mouthed bottle and secure the stopper.

2. Allow the contents to macerate for fourteen days, shaking the bottle vigorously once a day.

3. Pour off as much of the liquid as possible, press the residue, mix the liquids, and, having allowed the mixed products to stand twenty-four hours, filter.

Examples of Drugs requiring to be Treated by this Process.

Assafoetida, Guaiacum officinale.

Table No. 1.

Showing the amount of Rectified Spirit required to make Spirit of 40 O.P. with the water contained in each ounce of moist magma, and the amount of Spirit of 40 O.P. to be added in order to make a tincture in which 10 fluid ounces will represent as nearly as possible 1 ounce of the dry plant.

Moisture lost by the fresh plant in drying.

Rectified Spirit required.

Spiritof 40 O.P. to be added.

Fl. oz.

Fl. oz.

45 per cent....................

.. 2.80 ...............

.. 2.30

50 " ........................

...3.11................

.. 1.44

55 " .......................

..3.42 ..............

.. 0.59

58.5 „ ..................

..3.64 ................

No fresh plant containing more than 58.5 per cent. of water can yield a 1 in 10 tincture with spirit of 40 O.P.; either a more dilute spirit must be used, or a weaker tincture made. It is better, however, to use a more dilute spirit, than to make a weaker mother tincture.

Table No. 2.

Amount of Rectified Spirit required to make Spirit of 20 O.P. with the water contained in each ounce of moist magma.

Moisture lost in drying.

Rectified Spirit required.

Spirit of 20 O.P. to be added.

FL oz.

Fl. oz.

45 per cent.. .................

1.23 .............

3.86

50 „ ...................

1.37 ..................

3.17

55 „ ....................

1.51 ................

2.49

60 ,, ........................

1.64 ................

1.81

65 „ ........................

1.78. ................

1.13

70 „ ....................

1.92......... .........

0.44

73.5 „ ...................

.2.01...........

No fresh plant containing more than 73.5 per cent. of water can yield a 1 in 10 tincture with spirit of 20 O.P.; either a more dilute spirit must be used, or a weaker tincture made. It is better, however, to use a more dilute spirit, than to make a weaker mother tincture.

Table No. 3.

Amount of Rectified Spirit required to make Proof Spirit with the water contained in each ounce of moist magma.

Moisture lost in drying.

Rectified Spirit required.

Proof Spirit to be added.

PI. oz.

Fl oz.

45 ,, .................

. 0.69 ................ ............

4.39

50 „ ...........

. 0.77 .............. ............

3.76

55 „ ...........

. 0.85 ..............

314

60 „ ...........

. 0.92 .............. ............

2.52

65 „ ...........

. 1.00 .............. ............

1.89

70 „ ...........

. 1.08 .................

1.27

72.5 „ ...........

. 1.12 ...............

0.96

75 „ ...........

. 1.16 ........................

0.64

77.5 „ ...........

. 1.20 .......................

0.33

80 ,, ...........

. 1.24 ...............

0.02

c 2

No fresh plant containing upwards of 80.5 per cent. of water can yield a 1 in 10 tincture with proof spirit; either a more dilute spirit must be used, or a weaker tincture made.

It is better, however, to use a more dilute spirit, than to make a weaker mother tincture.

Table No. 4.

Amount of Rectified Spirit required to make Dilute Alcohol with the water contained in each ounce of moist magma.

Moisture lost in drying.

Rectified Spirit required.

FI. oz.

Dilute Alcohol to be added. Fl. oz.

45 per cent. ..............

0.45 ...........

4.62

50 „ ... ............

0.50 ...........

4.03

55 „ ................

0.55 ...........

3.43

60 „ ..............

0.60 ...........

2.83

65 „ ...............

065 ...........

2.23

70 „ ................

0.70 ...........

1.64

72.5 „ ...............

0.72 ...........

1.34

75 „ ...............

0.75 ...........

1.04

77.5 „ ...........................

0.77 ...........

0.74

80 „ ...........................

0.80 ...........

044

82.5 „ ............................

0.82 ...........

014

84 „ ................ ..........

0.84

No fresh plant containing more than 84 per cent. of water can yield a 1 in 10 tincture with dilute alcohol. As, however, the loss of moisture in some instances has been found to reach 93 or 94 per cent., it is considered more desirable that in such cases a weaker mother tincture should be prepared than a still more diluted alcohol used; but in every instance a sufficient quantity of such mother tincture must be used in making the first decimal attenuation to make it represent 1 part of dry plant in 100 parts of liquid, and thus uniform with all other first decimal attenuations of vegetable tinctures.