Contractions. - Quin-s. Ch-s.
Synonym. - Chininum Sulphuricum.
Present name. - Quinia Sulphate. (C20H14N2O2)2, H1So4,7H10.
This is prepared in large quantities by the manufacturing chemists, and is best obtained from them. Its purity, however, should be ascertained by the following
Characters and Tests. - Filiform silky snow-white crystals, of a pure intensely bitter taste, sparingly soluble in water, yet imparting to it a peculiar bluish tint. The solution gives with Chloride of Barium a white precipitate insoluble in Nitric Acid, and when treated first with solution of Chlorine and afterwards with Ammonia it becomes of a splendid emerald-green colour. Dissolves in pure Sulphuric Acid with a feeble yellowish tint, and undergoes no further change of colour when gently warmed. 10 grains with 10 minims of diluted Sulphuric Acid and half a fluid ounce of water form a perfect solution, from which Ammonia throws down a white precipitate. This re-dissolves on agitating the whole with half a fluid ounce of ether, without the production of any crystalline matter floating on the lower of the two strata, into which the agitated fluid separates on rest. 25 grains of the salt should lose 3.6 grains of water by drying at 212°.
Preparation. - Trituration for lx, unless Sulphuric Acid is added in excess. A solution of 1 in 15 can be made by adding a few drops of dilute Sulphuric Acid. The salt is sufficiently soluble in 20 O.P. spirit to allow of a 1 solution being made, and from this the higher attenuations should be prepared with rectified spirit.
Some practitioners prefer using the Muriate of Quinine, as it is more readily soluble and admits of a 1 in 10 solution being made, but further information is needed as to its action - indeed, a full proving of it is muck to be desired.
Reference to Horn. Proving. - Journ. fur. Arzn., ii.
Proper forms for dispensing. - Below 1, Trituration or Solution only, 1 and upwards, Tincture, Pilules, or Globules.