Contraction. - Sant.

Santonin. C15H18O3.

A crystalline neutral principle prepared from the Levant Wormseed, or Artemisia Contra. (Vide Cina, p. 111.)

It is called also Sanfonic Acid, though it has a neutral reaction; but it unites with alkalies to form salts, and is freely soluble in alkaline solutions.

It may be prepared according to the following process: -

Take of

Wormseed, bruised . . .

1 pound;

Slaked Lime ....

7 ounces;

Hydrochloric Acid . . .

A sufficiency;

Solution of Ammonia . . .

1/2 fluid ounce;

Rectified Spirit ....

14 fluid ounces;

Purified Animal Charcoal . .

60 grains;

Distilled Water ....

A sufficiency.

Boil the Wormseed with 1 gallon of the water and 5 ounces of the lime in a copper or tinned iron vessel for an hour, strain through a stout cloth, and express strongly. Mix the residue with half a gallon of the water and the rest of the lime, boil for half an hour, strain, and express as before. Mix the strained liquors, let them settle, decant the fluid from the deposit, and evaporate to the bulk of 2 1/2 pints. To the liquor, while hot, add, with diligent stirring, the Hydrochloric Acid until the fluid has become slightly and permanently acid, and set it aside for five days, that the precipitate may subside. Remove by skimming any oily matter which floats on the surface, and carefully decant the greater part of the fluid from the precipitate. Collect this on a paper filter, wash it first with cold distilled water till the washings pass colourless and nearly free from acid reaction, then with the solution of Ammonia previously diluted with 5 fluid ounces of the water, and lastly with cold distilled water till the washings pass colourless. Press the filter containing the precipitate between folds of filtering-paper, and dry with a gentle heat. Scrape the dry precipitate from the filter, and mix it with the Animal Charcoal. Pour on them 9 ounces of the rectified spirit, digest for half an hour, and boil for ten minutes. Filter while hot, wash the Charcoal with an ounce of boiling spirit, and set the filtrate aside for two days in a cool dark place to crystallize. Separate the mother liquor from the crystals, and concentrate to obtain a further product. Collect the crystals, let them drain, re-dissolve them in 4 ounces of boiling spirit, and let the solution crystallize as before. Lastly, dry the crystals on filtering-paper in the dark and preserve them in a bottle protected from light.

It should present the following

Characters and Tests. - Colourless, flat, rhombic prisms, feebly bitter, fusible and sublimable by a moderate beat; scarcely soluble in cold water, sparingly in boiling water, but abundantly in chloroform and boiling rectified spirit. Sunlight renders it yellow; not dissolved by diluted mineral acids; entirely destructible by a red heat with free access of air.

Preparations. - Trituration. Solution in warm rectified spirit for 1.

Reference to Horn. Proving. - Hale's New Remedies.

Proper forms for dispensing. - lx to 3, Trituration. 1 and upwards, Tincture, Pilules, or Globules.