The concepts of pleomorphism and symbiosis are in the current perspective inseparable from the name of the great researcher and microbiologist, Professor Dr. Günther Enderlein (1872-1968)

The basis for his work was the book by the French researcher A. Béchamp, titled "Microzymas". It described that a microorganism can, under precisely determined preconditions, occur in diverse developmental stages and, especially also in diversified forms, without the loss of its specific characteristics. The microorganism may vary from the smallest rungs of electron microscopic magnitude up to the large, multinucleic and highly developed stages, such as of bacteria and fungi.

Professor Dr. Günther Enderlein (1872-1968)

Moreover, Béchamp was able to prove that all animal and plant cells contain tiny particles which continue to live after the death of the organism and out of which microorganisms can develop. In this book, Béchamp laid the foundation for the concept of pleomorphism. The view that microorganisms can undergo a considerable variation in form, without losing their specific functions, stood and continues to stand diametrically opposed to the prevailing opinion of monomorphism, which admits only a single form and function to an organism. Naturally, that opinion has also resulted in a monomorphistic view of every disease process. Thus, in contrast to the opinion of Pasteur, that microorganisms simply exist without any developmental changes, Enderlein through intensive research came to the conclusion that the monomorphistic perspective of disease processes can no longer be maintained and had to be given up in favor of a pleomorphic perspective. He proved that every organism houses a primal plant germ in erythrocytes, which can very well become subject of a variation in form through exogenic influences.

Pleomorphism and Cyclogeny

The opinion represented by pleomorphic bacteriologists of the fundamental changeability of forms holds the possibility for microorganisms to abruptly change from originally avirulent into potentially virulent conditions.

Enderleindevoted the bulk of his scientific work which stretched for more than 40 years, to the complex question of pleomorphism, symbiosis and cyclogeny of microorganisms. He published over 500 scientific articles. His chief work was titled Bacteria Cyclogeny,Berlin, 1925. (It is currently published by Semmelweis Verlag, Hoya, in the German language; it is available in English language from Pleomorphic Product Sales Inc., Internet address: In this book he described in detail the changes and development of the parasite in its variable forms and its cycle.

This research was initiated by Enderlein in the year 1916, while he was working on typhoid. In blood using a darkfield microscope he observed mobile, tiniest living forms, named Spermits, which copulated with higher organized structures, whereafter the product of the copulation became suddenly invisible. Enderlein interpreted this as sexual processes, whereby tiniest, final products occurred, which are not visible to the eye of the light microscope. He named the symbiotic, primal plant germ in the erythrocyte Endobiont. This Endobiont lives in genuine symbiosis with the host organism, that is, with mutual benefits. Through outer factors, the Endobiont can multiply and develop - a process which can considerably disturb the symbiotic equilibrium. A healthy organism is capable of restoring the equilibrium. In this process, the more highly developed pathogenic germs are broken down into avirulent primitive forms through the copulation described by Enderlein. They leave the body through the natural organs of elimination.

The Nature of the Primal Germs and Symbiosis

However, the capacity for regenerating symbiosis is usually massively weakened through unhealthy lifestyles that are not in harmony with nature! Symbiosis is completed when the symbiont makes itself independent and becomes a parasite. In this, the Endobiont undergoes three basic phases: colloid-bacterium-fungus. This means, it develops from the apathogenic, non-mobile, tiniest albuminoid particle (Protit) - which is to be classified in size with the viruses (0.01 µm) - via the nonvirulent chondrit stage into the parasitic, pathogenic stages such as bacterium and fungus. According to Enderlein, they are not representing unchanging organisms that are independent of each other, but altogether they form a singular, common cycle, which has its origin in the colloidal, albuminoid substances that are contained inside of each particular cell.

Diseases of the Endobiosis Complex

Assisted by darkfield microscopy and using living blood, Enderlein was able to deliver clear proof of this vital, microbiological process in both its origin and cycle. As soon as this vital happening leaves a defined condition of equilibrium, all signs of parasitism occur, whereby out of the apathogenic symbionts (Protits and Chondrits)--with their enzymatic and metabolic active properties, they develop pathogenic microorganisms.

This explains, according to Enderlein, that all diseases of the Endobiosis complex are based on the upward development of the Endobiont into higher valenced, parasitic growth forms with their own metabolism that is harmful for body fluids. These disease processes are difficult to fathom, as they make themselves known in the beginning by functional disturbances in most diversified organs, such as, by headaches, high or low blood pressure, feeling poorly, unmotivated attitude, lack of appetite, drab complexion, coated tongue, wounds in the mouth, pimples, sores, hoarseness, catarrhs, ear noises, diarrhea, lowered capacity for seeing and hearing, depressions, weak concentration or poor memory.

Diseases, however, also indicate healing processes, which attempt to return a disturbed symbiosis to the original healthy condition. Whether the biological self-healing forces of the organism will win over the disease, or whether the symbiont is able to develop unchecked into a parasite, depends on the condition of the milieu in which the disturbance plays out. If the inner milieu is damaged through unhealthy nutrition and lifestyles, with their resultant disturbance of the acid-base equilibrium, through environmental toxins, through constant infections, or even through psychological depressions, then our self-healing forces are incapable of restoring our symbiotic equilibrium. Disease will manifest and damage the body. According to Enderlein, the milieu-conditioned cyclogenetic rise into higher stages of those microorganisms developed from the symbiont always determine the disease.