Aconite, or Monkshood, as it appears in commerce, is the dried, tuberous root of Aconitus Napellus ( Fam. Ranunculacece), a perennial herb about 1 metre high, growing in mountainous regions of Europe, Asia, and North America.

Properties: (a) Root:

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Properties: (b) Powder: Color...............................Odor --------------------........................ Taste_____...................................................

Assay. - Place 15 Gm. No. 40 Aconite Powder in a flask, add 150 mils ether, shake well, then let it stand 10 minutes; add 5 mils NH4OH, agitate vigorously every 10 minutes for 2 hours. Next add 15 mils distilled H20, shake well, let settle; then decant 100 mils of the solution, filtering it through purified cotton into a separator. Rinse funnel and cotton with a little ether. From this solution extract the alkaloid by repeated shakings out with weak H2SO4, collecting the acid washings in another separator; add NH4OH to decided alkalinity (litmus test), and continue extraction, with repeated shakings out with ether. Evaporate the ether washings to dryness, dissolve the alkaloids in the residue in precisely 5 mils N/10 H2SO4, V. S., and titrate the excess of acid with N/50 KOH, V. S., using T.S. cochineal as indicator. Each mil N/10 H2SO4, V. S., consumed corresponds to 64.539 mg of the ether-soluble alkaloids of Aconite.

What is. the alkaloidal strength of your sample?..................................................................................................

Official Preparations.

Extractum Aconiti - 1.8% to 2.2% Aconitina. Average dose, 0.01 Gm. Fluidextractum Aconiti - 0.45% to 0.55% Aconitina. Average close, 0.03 mil. Tinctura Aconiti - 0.045% to 0.055% Aconitina. Average dose, 0.3 mil. Aconitina, the most poisonous of all alkaloids. Dose, 0.00015 Gm. Therapeutics. Aconite is somewhat rarely indicated in sthenic types of acute inflammatory affections of the lungs or bronchi.