Cannabis is obtained from the flowering tops of Cannabis Sativa, or Indian Hemp, a sub-tropical plant. It owes its activity to a red oil, cannabinol, a phenolaldehyde with the composition OH.C20H28COH.

Pharmacodynamics.

Central Nervous System. - Cannabis produces a slow downward depression of the mental faculties, with the exception of the faculty of imagination, which seems to be exalted abnormally, and perverted. There is some cerebellar involvement. The cord is first stimulated, then later depressed.

Muscular System. - A feeling of lassitude is induced.

Respiration somewhat slowed from centric action; said, however, to be accelerated if drug is inhaled.

Heart slowed moderately; accelerated if drug is inhaled.

Blood-pressure. - Slightly elevated, action probably centric.

Pupil generally dilated. Centric action on motor oculi.

Alimentary Canal. - Reflexly stimulated.

Secretory glands somewhat stimulated, especially the parotids.

Metabolism. - Data inconclusive.

Temperature. - Apparently not affected.

Absorption. - Fairly rapid.

Excretion. - Via kidneys, in combination with glycuronic acid.

Tolerance. - Some degree rapidly acquired.

Symptoms.

(Varying greatly with different individuals):

Therapeutic Doses.

Lassitude.

Feeling of heaviness. Drowsiness and dreaminess. Diminished sense of touch and pain. Distorted ideas of time and space, mere fractions seeming vast.

Merriment and self-satisfaction.

Wonderful visions and extravagant imaginings.

Sometimes great fear of imminent, indefinite danger.

Partial or recurrent unconsciousness.

Deep tranquil sleep.

Cannabis may occasionally be advantageously employed in cases of insomnia due to nervousness or nervous exhaustion.

Dosage.

Extractum Cannabis 0.01 to 0.03 Gm. Fluidextractum Cannabis, 0.06 to 0.2 mil. Tinctura Cannabis 0.6 to 2 mils.

Cannabis 65

Crimson = stimulation. Violet = depression.