Colocynth is the pulp of the dried fruit of Citrullus Colocynthis (Fam. Cucurbi-tacece), a native of Southwestern Asia and Northern Africa.

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Colocynth is used in various pills for its strong purgative properties. An official preparation is the Extract, from which is made the Compound Extract, which is one ingredient of Pilulae Catharticae Compositae.