Suppositories are conical, cylindrical, or spheroidal preparations made by combining medicinal substances with some other substance, like glycerinated gelatin or cacao butter, that melts but slowly at body temperatures. They are used to favor prolonged application of medicines to the walls of the various body cavities.

Make the official Suppositoria Glycerini as follows: Dissolve 0.05 Gm. monohy-drated sodium carbonate in 0.5 mil water; add 2.7 mil glycerin and 0.2 Gm. stearic acid; cover, and heat the mixture over a water bath until all the CO2 has been driven off and the liquid is clear (15 minutes or more). Then pour the material into a suitable mold (a small conical graduate will do); cool in flowing water, and, when it is firm, remove from the mold and examine.

What is its appearance?........................................................................................................................................................................

How does it feel?...........................................................................................................................................................................................

Make a Suppository as follows: To 0.5 Gm. tannic acid add an equal quantity of well-grated oil of theobroma; mix the two thoroughly in a mortar; then add a small amount of melted oil of theobroma; mix well; and as congelation is about to take place pour the material into a suitable mold. Cool until set; remove, and examine.

Make a Suppository as follows: Dissolve I mil ichthyol in 3 Gm. glycerine; add 5 Gm. melted glycerinated gelatine; mix the ingredients thoroughly, and at once pour into a small test-tube which has been coated internally with a very thin film of liquid petrolatum. Cool until Suppository is firmly set. (Keep in tightly closed containers in a cool place.)

Compare the merits of these three Suppositories:

Suppository A:..................................................................................................................................................................................................

Suppository B:..................................................................................................................................................................................................

Suppository C:..................................................................................................................................................................................................

Also take 1 Gm. pieces from each, and compare their melting periods when immersed in water of a temperature of 38° C.

A:.......................................................................... B: ................................................................ C:..........................................................................