Vaccine Virus consists of the specially prepared, glycerinated, lymphocytic exudates found in the dermal manifestations of vaccinia in young bovines. It is prepared in selected establishments, working under a Federal license, and under requirements and regulations prescribed by the U. S. Public Health Service.

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Vaccine Virus has an almost universal use in the production of vaccinia, or cow-pox, a single attack of which mild disease almost always affords adequate immunity against variola.