This approximates closely to phenacetin; occurs in colorless, odorless scales, soluble in alcohol, acetone, glycerin, fatty oils, slightly in water, benzene, and ether. Dose, gr. 2 - 8 (.13 - .5 Gm.).
Properties and Uses. - Antipyretic; typhoid, rheumatism.
Acetphenetidin. Acetphenetidinum. Phenacetin, C6H4.OC2H5.-NHC2H3O. - (Official.) See page 865.
Thermodin. Phenacetin-urethane. Acetylparethoxyphenylure-thane, C13H17NO4.
Manufacture: This compound of phenacetin and urethane is obtained by the action of ethyl chloro-carbonate on parapheiietidin, thereby forming paraethoxypheuyl-urethane, which is converted into the ethyl form by heating with acetic anhydride. Occurs in colorless, odorless, tasteless crystals, melting at 86° C. (187° F.), insoluble in water.
Properties and Uses. - Analgesic, antipyretic, antiseptic; typhoid, pneumonia, influenza, tuberculosis, febrile conditions in general. Dose, analgesic, gr. 15-20 (1-1.3 Gm.); antipyretic, gr. 5-10 (.3-.6 Gm.).
Chinaphenine. Quinine Carbo-phenetidide. Phenetidin Quinine Carbonic Acid Ester, C29H33N3O4.
Manufacture: By action of quinine on p-ethoxyphenyl carbarnic acid chloride. Occurs as a white, odorless, tasteless powder, soluble in alcohol, ether, chloroform, benzene, sparingly in water, forms soluble salts with acids and by latter decomposed with liberation of quinine.
Properties and Uses. - Antiperiodic, antipyretic, anodyne - resembling quinine and phenacetin combined with the advantages of tastelessness and freedom of cinchonism. Malaria, neuralgia, la grippe, whooping-cough, etc. Dose, gr. 2-5-15 (.13-.3-1 Gm.).
Holocaine. Holocainum. - Para-diethoxyethenyl-diphenylamidine, OC2H5.C6H4NHC.CH3.N.C6H4.O.C2H5 + H2O.
Manufacture: May be obtained by combining in molecular quantities phenacetin and para-phenetidin, when water separates, leaving the base - OC2H5.C6H4NHC.O.CH3 + H2N.C6H4.O.C2H5 = OC2H5.C6H4-NHC.CH3N.C6H4.O.C9H + H2O. It occurs in beautiful white needles, which melt at 120° C. (248° F.), soluble in water (40), undecom-posed by boiling, which should be accomplished in a porcelain vessel as the solutions attack glass. The hydrochloride, in white crystals, is the salt mostly used, in 1 p. c. solution; it is slightly bitter, neutral, and may be kept for months without change.
Properties and Uses. - Local anaesthetic, germicide, antiseptic, as a substitute for cocaine in ocular surgery. The anaesthesia is produced within a minute and lasts for a quarter of an hour, the burning being about as intense as that following cocaine. Unlike cocaine, it does not change the pupil, the accommodation, or intraocular pressure, does not contract bloodvessels, and additionally acts as an antiseptic. The disadvantages are that it requires to be renewed in 10 to 15 minutes, and is 5 times more toxic than cocaine, hence cannot be used hypodermically; 1 p. c. solution causes a degree of anaesthesia equal to a 3 - 4 p. c. solution of cocaine.
Lactophenin. Lactopheminum. - Lactyl-phenetidine.
Manufacture: Allow lactic acid to act on phenetidine in the presence of dehydrating substances. It is more soluble than phenacetin, and differs from it only in using lactic instead of acetic acid; occurs as a bitter, odorless, crystalline powder, soluble in alcohol (9), water (320), melts at 118° C. (244° P.). Dose, gr. 8-15 (.5-1 Gm.).
Properties and Uses. - Antipyretic, sedative, analgesic, hypnotic (between sulphonal and urethane); better tolerated than antipyrine, occasioning neither collapse nor cyanosis; rheumatism, pneumonia, typhoid and scarlet fevers, influenza, septicaemia.
Sedatin. Para-valeryl-amido-(phenetol) phenetidin.
Manufacture: Act on para-amido-phenetol with valeric acid or valeryl chloride. It crystallizes in needles, slightly soluble in acetone, chloroform, ether, insoluble in water. Dose, gr. 1-5 (.06-.3 Gm.).
Properties and Uses. - Resembles antipyrine; sedative, anti-neuralgic.
Benzanilid. Benzoyl-anilid. - Phenylbenzamide.
Manufacture: Act on aniline with benzoyl chloride in the presence of caustic soda. It is in colorless scales, soluble in cold (58), hot alcohol (7), insoluble in water; melts at 162° C, (324° F.).
Benzanilid bears the same relation to benzoic acid that acetanilid does to acetic acid. Dose, gr. 2-8 (.13-5 Gm.); children gr. 1-5 (.06-.3 Gm.).
Properties and Uses. - Antipyretic, especially in fevers of children.
Phenocoll Hydrochloride. Phenocollum Hydrochloridum. - Glycocoll-para-phenetidin hydrochloride.
Manufacture: Chlor-acetyl chloride acts on para-amido-phenetol, and the resulting product is treated with ammonia. This is a result of many attempts to form a soluble phenacetin; it is a white crystal, line powder, soluble in water (20). When boiled with acids or alkalies it is broken up into phenacetin and glycocoll, and this latter base is precipitated always upon adding ammonia, alkalies, or alkaline carbonates to any of its solutions. Dose, gr. 5-15 (.3-1 Gm.), in capsules.