Properties and Uses. - Antipyretic, antineuralgic, antirheumatic, diaphoretic; hectic fever, chronic and acute rheumatism, neuralgia, hypnotic.

Gallanilide. Gallanol. - Gallinol.

C6H5NH,CO,C6H2(OH)3

Manufacture: By heating aniline to 150° C. (302° F.) for an hour with tannic or gallic acid (C6H2(OH)3COOH); the resulting product is purified by crystallization from diluted alcohol. In colorless, bitter crystals, when free from water melts at 205° C. (401° F.), soluble in hot water, alcohol, ether, or alkalies, slightly in cold water.

Properties and Uses. - Chiefly externally for skin diseases, instead of chrysarobin.

Phenocoll Salicylate. Phenocollum Salicylicum. - Salocoll.

C6H4(OC2H5)NHCOCH2(NH2)C7H6O3=

This is soluble in hot water, from which it crystallizes in fine needles; its aqueous solution is neutral in reaction and has a sweet taste. Dose, gr. 5-15 (.3-1 Gm.).

Properties and Uses. - Antipyretic, antirheumatic; combines those of phenocoll and salicylic acid.

Hydracetin. Pyrodin. - Acetyl-phenyl-hydrazine.

Manufacture: Heat together acetic anhydride, or acetic acid and phenyl-hydrazine, dissolve in boiling water, crystallize. It is in colorless, shining, odorless, tasteless crystals, soluble in alcohol, hot water; melts at 128° C. (263° F.); when boiled with HO splits into acetic acid and phenyl-hydrazine hydrochloride. Dose, gr. 1/6 - 1 (.01-.06 Gm.), ter die.

Properties and Uses. - Antipyretic, antineuralgic; hectic fever of phthisis, night-sweats. Externally - allied in effect to pyrogallol and chrysarobin in skin diseases (psoriasis, etc.). Apply in ointment 5-10 p. c.; when stronger may poison the system by absorption.

VI. Aldehydes and Ketones. Hypnone. Acetophenone. - Phenyl-methyl-ketone.

Manufacture: 1. Distil a mixture of calcium acetate and benzoate. 2. Act on benzene in the presence of A1C13 with acetyl chloride. It is in white crystals, melting at 20° C. (69° F.); when in liquid form it is slightly yellow, bitter almond odor, bitter taste, hence objectionable to some persons. Dose, gr. or ev-15 (.3-1 Ml. (Cc.) or Gm.), which must be increased largely upon usage.

Properties and Uses. - Hypnotic, but somewhat uncertain.

Gallacetophenone. Tri-oxy-acetophenone. - Alizarin Yellow.

Manufacture: Heat to 145-150° C. (293-302° F.) for a short time a mixture of pyrogallol 1, zinc chloride and glacial acetic acid, each 1 1/2; to this hot fused mass add water, when gallacetophenone separates out, which may be purified by crystallizing from hot water. It occurs in dirty, flesh-color, powdery crystals, soluble in alcohol, ether, glycerin, hot water, or cold water (600).

Properties and Uses. - Antiseptic; skin affections (psoriasis, etc.), in 10 p. c. solutions or ointments, being a good substitute for pyrogallol, as it does not stain nor poison so easily.

Agathin. Salicyl Aldehyde-methyl-phenyl-hydrazine.

Manufacture: By the direct union of methyl-phenyl-hydrazine and salicylic aldehyde. It is in small greenish crystals, soluble in alcohol, benzene, ether, insoluble in water. Dose, gr. 5-10 (.3-.6 Gm.).

Properties and Uses. - Antineuralgic; neuralgia, rheumatism.

8. Carboxyl Derivatives (CO2H).

Benzoic Acid. Acidum Benzoicum, C7H6O2. - (Official.) See page 458.

Benzosulphinide. Benzosulphinidum, Saccharin,

- {Official.) See page 866.

9. Oxybenzoic (Salicylic) Derivatives.

Salicylic Acid. Acidum Salicylicum, C7H6O3. - (Official.) See page

858.

Methyl Salicylas. Artificial Oil of Wintergreen,

- {Official.) See page 450.

Di-iodo-salicylic Acid, C6H2I2(OH)COOH.

Manufacture: To an alcoholic solution of salicylic acid add iodine and iodic acid. Occurs as a crystalline powder, sweetish taste, melts at 220-230° C. (428-446° F.) with decomposition, soluble in alcohol, ether, boiling water (660), cold water (1500). Dose, gr. 5-20 (.3-1.3 Gm.).

Properties and Uses. - Analgesic, antiseptic, antipyretic.

Sodium di-thio-salicylate.

Manufacture: Heat together salicylic acid and sulphur chloride. It is a gray, hygroscopic, amorphous powder, soluble in water. Dose, gr. 5-15 (.3-1 Gm.). . Properties and Uses. - Antiseptic, antipyretic, analgesic.

Phenyl Salicylate. Phenylis Salicylas. Salol, C6H5C7H5O3. - (Official.) See page 859.

Aspirin. Acetyl-salicylic Acid, C6H4COOHCO2CH2.

Manufacture: By prolonged heating salicylic acid (50) and acetic anhydride or acetyl chloride (75) at 150° C. (302° F.), recrystallizing from chloroform. Occurs in small, colorless, crystalline needles, acidulous taste, melting at 135° C. (275° F.), soluble in alcohol, ether, chloroform, water (100), in which upon boiling or with alkalies it splits into components - acetic acid and salicylic acid (salicylate); 57 distinguished from salicylic acid by adding ferric chloride to aqueous or alcoholic solution - no violet color. Should not be confounded with salicylo-acetic acid in glassy scales and used as an antiseptic.