This section is from the book "Materia Medica And Therapeutics Inorganic Substances", by Charles D. F. Phillips. Also available from Amazon: Materia medica and therapeutics.
The prolonged administration of iodide of potassium in chronic Bright's disease is said to have retarded fibroid changes in the kidney, and induced general improvement in nutrition (Bartholow). Dr. Crequi (Brussels) recommends it for the second or parenchymatous stage. Using commonly 6 gr. or more daily, he has sometimes given as much as 6 dr. in the day, with bismuth or opium to control irritative effects. He presumes the iodide acts by limiting morbid secretion in the renal tubules (Lancet, i., 1871). In subacute cases, with dropsy, I have frequently used this remedy in doses of 3 to 4 gr., and have seen apparent advantage from it. I think it hastens absorption of inflammatory products, but, from what has been already stated as to the possibility of its causing renal congestion (v. p. 67), it must be considered unsuitable in acute nephritis, unless in fractional doses.