This section is from the book "Materia Medica And Therapeutics Inorganic Substances", by Charles D. F. Phillips. Also available from Amazon: Materia medica and therapeutics.
The great value of bromides in nerve-disorder has led us, perhaps, to think less of them as remedies in scrofulosis and glandular enlargements, but they are often very useful in such conditions. Dr. Wilks recorded their good effect in bronchocele (Medical Times, ii., 1861, p. 635), and I have used them frequently and successfully in gland-swellings connected with struma. They have been by others recommended in combination with liquor potassae (Lancet, i., 1860, p. 62). The bromo-iodine waters of Kreuznach and Woodhall Spa are also good forms for their administration.
Dr. Robert Williams found the bromide of potassium extremely useful in reducing enlargement of the spleen (malarial), and, in an appendix to his classic work on Morbid Poisons, gives several striking instances of its value when other and better known medicines had failed.
Mr. Spencer Wells has confirmed the observations of Dr. Williams, and, amongst other cases, has recorded that of a child, aged eight, extremely emaciated, suffering from hectic, and with the abdomen distended by an enormously large spleen, the lower edge of which extended to the pubes. The case seemed apparently beyond the power of medicine, but yet, under the influence of 3 gr. of bromide thrice daily, some diminution was produced within a week; under 5 gr. this continued, until at the end of a few weeks the viscus was above the umbilicus, and the child convalescent. The case was either connected with ague or with blood-poisoning from unhealthy atmosphere, and is a very remarkable one. Acting on the suggestion of Mr. Spencer Wells, I have myself used the drug in similar cases, but in larger doses, and have been pleased with it. Claude Bernard has recorded equally good results, but with doses of 20 to 40 gr. daily (Bulletin, 1874).