When this disorder is dependent upon anaemia, iron is clearly indicated, and may prove of great service, as it did in the hands of Elliotson, who used large doses of oxide (Medical Times, i., I869, p. 136). Sir T. Watson recommends the carbonate. Many cases occur about the time of commencing puberty, and others evince obscure rheumatic symptoms: and in these also iron is useful, but it often acts better when taken in conjunction with arsenic.