A good deal of irritation with hyperaesthesia may be determined in the skin and the conjunctivae, as well as in the buccal membrane, by the use of phosphorus. It is not easy to say whether this is caused by the elimination of the drug, or by the presence of biliary compounds from altered liver-function, or from impaired blood-condition; the icteric tint has been already mentioned. In cases of poisoning, erythematous and hemorrhagic patches occur in the skin, and increased perspiration has been traced to the medicinal use of the drug.