A number of anomalous symptoms which may be referred to this cause are relieved by bromides; for instance, "sudden numbness, coldness, deadness, or pricking sensations in one or more limbs; distressing, indefinable feelings in the epigastrium or abdomen; or sensations akin to rigor, with much anxiety and palpitation or ' fluttering ' of the heart." In such cases the local circulation may be interfered with, the pulse in one arm becoming irregular and faltering, while in the other it may remain unaltered, and the heart-beats continue normal.