When these conditions occur in connection with a generally demented state, the bromides do not seem to relieve so much as might have been expected. My friend, Dr. Mackey, when in charge of a large asylum at the time when bromides were first introduced, and were specially recommended in sexual cases, gave the potassium salt to many of the younger patients, especially youths addicted to masturbation, but generally with the result of inducing extreme and miserable depression, without controlling the symptoms. Dr. Williams also noted that in his thirty-seven insane cases the sexual system was not at all, or but slightly affected. Even in subjects of average mental health, but addicted to onanism, the bromides, though they lessened the venereal appetite for a time, effected no cure in Dr. Bill's experience, and he concluded that they could lessen only excentric sexual irritation (American Journal, July, 1868). In this they certainly are highly valuable. In the few cases that I have seen approaching to nymphomania, benefit was derived from the bromides alone, but they act best when given in conjunction with bath, counter-irritation, and moral agencies. Dr. E. C. Clarke and Dr. Begbie have recorded very satisfactory results.