This system often shares in the general stimulation and irritation induced by small doses of arsenic, as has been noticed in the arsenic-eaters of Styria, and in experiments on animals. Gies especially remarked it in the cocks used for his observations on bone-growth (loc. cit.). Clinically, Prof. Charcot was led in two cases to a contrary conclusion, but Devergie showed that this could not be sustained, and that stimulation to some extent was not unusual (Bulletin de Therapeu-tique, 1864); this, however, is not such as to preclude the medicinal use of the drug, and it finds its place in the treatment of amenorrhoea.

In arsenical poisoning, inflammation of the genitals has been said to occur (Hunt), and certainly much irritation of them has been present, especially in women; but it would seem to be connected rather with the general irritation of mucous membrane than with these special organs. The young of animals subjected to an arsenical course were born dead, but fully developed; their birth was delayed rather than premature (Th. Gies, loc. cit.), and no markedly injurious effect can be traced on the uterus. In many instances of arsenic being taken by pregnant women, even when with fatal results, abortion has not occurred (Guy's Reports, vol. vii.).