This section is from the book "Materia Medica And Therapeutics Inorganic Substances", by Charles D. F. Phillips. Also available from Amazon: Materia medica and therapeutics.
The genital system is stimulated by iodine, sexual desire being increased under its use (Jorg); an increased flow of blood to the uterus is sometimes determined by it. If the iodide of potassium has a similar effect, it is much less in degree.
The effect of either preparation upon the urine is variable. Begbie speaks of iodide of potassium as one of the best diuretics (Lancet, ii., 1875), while Handfield Jones, out of six cases observed, found the secretion increased in three, but diminished in two (Beale's Archives, No. 3). Rabuteau observed no diuresis from 15 grain doses. Wohler, giving iodine to a dog, noted increase of urination, but only in proportion to increased quantity of water drunk (Zeitschrift, 1824). Bassefreund, from observations on himself, concluded that the urine in healthy persons was not augmented under iodides; at first it was rather lessened in quantity (Canstatt: Jahrb., 1859). Very large doses may irritate and congest the kidney, and induce albuminuria, in which case the amount secreted would naturally be lessened (Gubler). Mr. Hutchinson "suspects that iodides may cause Bright's disease" (Lancet, ii., 1876). Dr. Simon found that albuminuria occurred in the majority of children that had tincture of iodine externally applied, whether to the scalp, the chest, or the knee (British Medical Journal, ii., 1876), although, from the analyses of Dr. Ord in a case of iodine-poisoning, the urinary precipitate in such cases would seem to be mucin rather than albumen. As remarked by Mr. Spencer Wells, the alkaline iodides have some power in dissolving uric acid, but this is due probably to the alkali rather than the iodine. H. Jones obtained very discordant results from iodide of potassium; in some cases the uric acid, urea, and other constituents being diminished, in others increased.
In Dr. Ord's case, urea and uric acid were largely increased. In dia-betics taking iodide, the same thing occurred (Bouchardat).
On the other hand, Rabuteau, taking daily, for five days, 15 gr. of iodide of potassium, reported marked diminution in his urea-excretion- to the extent, some days, of 40 per cent. during the period of experiment, and for nearly a fortnight afterward.