This section is from the book "Materia Medica And Therapeutics Inorganic Substances", by Charles D. F. Phillips. Also available from Amazon: Materia medica and therapeutics.
There is but little evidence of any stimulus to the generative function or organs exerted by phosphorus given to healthy subjects, whatever may be its power in certain forms of disease. The stimulation that has been noted in some cases, both of men and animals, was not special, but merely a part of the general stimulus to the whole nervous system. Leroy, indeed, and some other French authors, have reported some temporary genital stimulation from large doses, and, in a few cases of poisoning, irritation and excitement of the genitalia have been recorded, but they are to be explained as above. Thompson gave to two healthy adults 1 to 1 1/2 gr. of zinc phosphide daily for eight or nine days, and to another 1/8 to 1/6 gr. of free phosphorus until symptoms of incipient poisoning arose, but without any trace of aphrodisiac effect. Dr. Eames has reported similar negative results from observations with phosphuretted oil, and Mr. Bradley's experience is to the same effect.
With special reference to this point, I have myself carefully experimented upon twenty healthy men. Ten of them took 1/10 gr. daily for a fortnight; five took 1/3 gr. each day for a similar period; and the other five took 1/2 gr. every third day for five successive doses. Toxic symptoms occurred in some of the subjects, but, except possibly in one of the last set, no sign or feeling of increased sexual excitement was observed. I have, however, seen men from forty to sixty years of age, apparently in good health, but suffering from complete loss of generative power (in consequence either of previous sexual abuse, or of overtaxed brain and nervous system), in whom very small doses - 1/200 gr. thrice daily - caused weak erections and involuntary emissions, but mental depression was developed to such an extent as to compel the suspension of the drug: this implies a state of irritation, but certainly not one of increased tone or strength.
With regard to its influence upon the uterus, we have evidence that long-suppressed menstruation may reappear under its continued use in small doses, but this may reasonably be connected with improvement in the blood-condition rather than with specific stimulation; in cases of poisoning, however, uterine hemorrhage and abortion occur (v. p. 41).
The urine under the influence of phosphorus becomes high-colored and loaded, sometimes phosphorescent, and with a smell of violets, or of sulphur.
Husemann reports the nitrogenous constituents increased in amount, and more recently, in dogs poisoned by phosphorus, Bauer found the excretion of urea notably increased - 20 to 90 per cent. above normal (Zeitschrift fur Biologie, Bd. xiv., Hft. 4, 1878); the phosphates are unaltered in quantity (Derlon). Leucin, tyrosin, and paralactic acid have been found in cases of poisoning.