I have already mentioned that Mr. Ure found 1 to 2 dr. of the sulphate act as a cholagogue purgative (Pereira), and Dr. Goolden gave it in cases of enlarged liver with dark or pale stools, and jaundice, when no abscess or acute symptoms were present. Most of the patients (at the Dreadnought Hospital) were in weak condition, having returned from India, and he sought for a non-mercurial remedy to stimulate the liver. He says that 10 or 20 gr. of sulphate of manganese, though at first it excited nausea or vomiting, soon acted on the bowels to the marked relief of the patient, and with rapid clearing away of the jaundice (Lancet, 1840). This favorable result has, however, not been corroborated by the experience of others, but recently Dr. Goolden has written to direct attention again to the subject, stating that he has continued to use the remedy with success in hepatic dropsy, hemorrhoids, bronchial congestion, hypochondriasis, etc.: he usually combines it with Epsom salts, in a glass of effervescent water (Lancet, i., 1878).

Polli and Galamini state that they have cured cases of biliary calculus by peroxide of manganese, given in gramme doses daily as an electuary: they explain the solution of the calculi by the action of oxygen from the peroxide upon the cholesterine (Gazette de Paris, 1856).