The fact just recorded of phosphorus stimulating the growth of bone - a tissue of which it forms a component part - has led to the inference that it can stimulate the nutrition of nerve-tissue, of which also it forms a normal constituent; but the evidence on this subject is rather clinical than experimental. Gubler describes the effect of 1/30 to 1/15 gr. to be a "general sense of stimulation more complete than that caused by coffee, more active than that produced by opium." A. Thompson speaks of it as producing "exhilaration and increased capacity for exertion, both mental and physical, and an effect like that of alcohol without the subsequent depression." He states also that if 1/2 to 1 gr. be taken in the course of twenty-four hours, the feelings described are more sustained, and transient giddiness or quasi-intoxication occurs. There seems to me some exaggeration in these accounts, but it is within my own experience that a general tonic effect may be obtained from these and smaller quantities of the drug. In cases where poisonous symptoms are developed, marked excitement, tremor, and spasmodic muscular twitching occur, and, in severe cases, cramp or partial paralysis, delirium, convulsion, collapse, or coma.