This is, in most cases, dependent on some fault in primary digestion (I have known it produced apparently by continued use of a drinking water containing much lime), besides the renal symptoms, malaise, depression, and hypochondriacal feelings accompany the malady. Relief may be given by the mineral acids conjoined with attention to diet and drinking water; and of the different acids the nitro-hydrochloric seems to be the best, as originally stated by Dr. Prout ("Stomach Disease," p. 73); he advised its continuance for a few weeks at a time, or until lithates appeared in the urine. Deposits of cystine are relieved by the same treatment.