Prof. Bouchut restricted the value of arsenic in glandular disease to cases where this was superficial and limited, and where cachexia was not present, but later experience has proved the remedy to be more generally useful than he believed. I have seen it of much service, especially when combined with iron, in relieving cachexia, and Billroth has recorded a remarkable case - that of a woman, aged forty, in whom the cervical, axillary, and other glands, as well as the spleen, were affected, and who recovered under Fowler's solution, taking 5 to 20 drops for a dose. Billroth's observations have not been often repeated, but have been recently supported by Dr. Winiwarter. He records good results in cases of malignant lymphoma, or Hodgkins' disease, a malady limited to lymphatic structures, and to be distinguished from a sarcoma commencing in the glands, and spreading from thence. In the latter condition arsenic has no influence: neither is "Hodgkins' disease" to be confounded with scrofula, for there is no tendency to suppuration; nor with leukaemia, for there is no increase of white corpuscles. The malady referred to occurs in strong young persons, often begins in the cervical glands, which enlarge separately, and it is fatal if left untreated; it has been observed to follow intermittent fever. Under the use of arsenic, continued for three or four months or more, and also injected into the tumors, they have disappeared, at least for several years, and the patients have become convalescent. It is recommended to begin with 5 min. of Fowler's solution and 5 min. of tinct. ferri night and morning, cautiously increasing the dose up to 30 to 40 min., or to the production of physiological effects (Stricker's Jahrb., 1877, part ii.).