This section is from the book "Materia Medica And Therapeutics Inorganic Substances", by Charles D. F. Phillips. Also available from Amazon: Materia medica and therapeutics.
Aime Martin and Oberlin have recently published the resuits of fifty cases of secondary and tertiary syphilitic affections treated with sulphate of copper; in many of these it is said to have acted more promptly than mercury; only in one patient vomiting took place on the first day, but very soon the metal was borne well; a green margin of the gums without an inflamed state of the mucous membrane was observed in a few cases, but disappeared soon; the remedy was given in solution, and 4 to 8 or 12 milligr. were used daily. To a full bath 20 grammes were added (Gazette Medicale de Paris, November 15, 1880). Zeissl has tried copper in syphilis, but his results were only partly satisfactory (Wien. Med. Presse, November 29, 1880).
Cupri sulphas: as a tonic and astringent, 1/4 gr. to 1 or 2 gr.; as emetic, 5 to 8 gr. (for adults) - best administered in divided doses at short intervals; a child may have 1/8 to 1/4 gr., according to age and strength, repeated every five to fifteen minutes till vomiting occur; it should then be omitted for a time, or purging may succeed. The oxide of copper has been used in doses of 1/4 to 1 or 2 gr., and the double chloride with ammonium in 1/4 or 1/2-gr. doses, every two or three hours. A tinctura cupri acetici has obtained some favor on the Continent under the auspices of Rademacher. It is prepared by mixing 24 parts of copper with 30 parts of acetate of lead in 136 parts of distilled water: boiling this in copper vessels, then adding 104 parts of spirit, and macerating for four weeks in a closed glass vessel, then filtering. It forms a green liquid of metallic taste, and is the chief remedy for all "copper diseases," and "especially for hyperaemiae, stases, and exudations" - 5 to 15 drops and upward are given thrice daily (Kissel, Husemann). As a lotion, 1 to 2 gr. of sulphate in the ounce, as a parasiticide, 10 to 20 gr. to the ounce may be used, and a stimulating astringent ointment may be made with ung. sambuci in the same proportion.
[Preparations, U. S. P. - Cuprum ammoniatum, Cupri subacetas, and Cupri sulphas.]