This section is from the book "Materia Medica And Therapeutics Inorganic Substances", by Charles D. F. Phillips. Also available from Amazon: Materia medica and therapeutics.
Gonorrhoeal attacks in females can sometimes be cut short by one or two paintings of the vagina, cervix uteri, labia, and urethral canal with strong tincture of iodine, after first cleansing away the discharge. The pain lasts for some hours, but the result usually is good.
At the commencement an injection containing 30 or even 60 gr. to the ounce has sometimes succeeded in aborting the malady, but it causes severe pain, and may lead to serious inflammation. In the female, a similar solution applied thoroughly, per speculum, to the vagina, has given better results, and offers less risk on account of the anatomical conditions; but, as a rule, the frequent use of a weaker solution is more advisable. I recommend, so soon as the acute inflammatory stage begins to subside, an injection containing 1/2 to 1 gr. in the ounce every three or four hours; or sometimes a strength of only 1 gr. in 8 oz., to be injected every half-hour for the first eight hours, and afterward every four hours until cure is effected, which should be in twenty-four to forty-eight hours. I have had most excellent results in many obstinate cases from this method; it should not be wholly omitted at the end of forty-eight hours, but used once, or twice, or, if the discharge continues, a little oftener for the following two or three days.
In the chronic stages of urethral inflammation, sulphate of iron forms a good injection. I recommend about 12 gr. with 1/2 oz. of laudanum, in 8 or 10 oz. of water - a little to be used three times a day; another form, recommended by Dr. Ringer, contains 1/2 dr. of the per-chloride tincture, with 1 dr. of laudanum in 1/2 pint water. "It often speedily checks the discharge, and relieves pain on micturition." Baru-del, writing from a large experience, would absolutely restrict the local use of perchloride to chronic cases, but he advocates it internally for all forms of urethritis, acute and chronic (Medico - Chirurgical Review, i., 1859, p. 244). I would not myself recommend its use, even internally, in acute stages, but in the later ones of gonorrhoea, or gleet, full doses of 10 to 15 min. are of real advantage. Pereira recommended the remedy in combination with tincture of cantharides.