This section is from the book "Materia Medica And Therapeutics Inorganic Substances", by Charles D. F. Phillips. Also available from Amazon: Materia medica and therapeutics.
The urine is commonly increased in quantity for a time under small doses, but with their continuance renal irritation may be induced, so that the secretion is lessened, and elimination of the drug impeded. Hence it is an important practical point to examine the urinary condition during arsenical treatment, and to use, if necessary, alkaline diuretics. Lolliot traced haematuria and albuminuria to arsenic, and, in a case of pythisis, carefully recorded by Dr. Weir Mitchell, albuminus urine was induced by 4 to 12 min. of Fowler's solution given daily for a few weeks; anasarca also set in, and these conditions ceased and then recurred concurrently with omitting and resuming the medicine (New York Medical Journal, vol. i.). After poisonous doses the urine, though at first it may be passed too often, soon becomes scanty, and its evacuation causes scalding pain and tenesmus; it may contain blood, albumen, and casts, and sooner or later becomes suppressed; urethritis has been already mentioned.