This section is from the book "Recent Materia Medica: Notes On Their Origin And Therapeutics", by F. Harwood Lescher. Also available from Amazon: Recent materia medica.
Hydrochloride of Phenylhydrochinazolin.
A new stomachic and digestive agent, toning up the functions of the stomach. A bitter, whitish crystalline powder, soluble in hot water and alcohol, though Orexin itself is insoluble.
Therapeutics. A dose of 3 to 5 grains gives a feeling of hunger, accompanied with slight irritation of mucous membrane.
The following formula has been used:
R. Orexin hydrochlor, 3 gs.
Ext. Gentian.
Pulv. rad. Altheae, q.s. f. pil. xx.
Dose 3 to 5 pills in a cup of beef-tea, once or twice daily: i.e., 2 to 4, rising to 7, grains daily.
The large amount of hot liquid to be taken with, or immediately after the dose of Orexin, is to prevent the irritating effects of this substance on the coats of the stomach.
"The hydrochloric acid of the gastric juice appears about an hour earlier, with its use." - Penzoldt. See also Pharm. Journ., 31-5-90.
 
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