This section is from the book "Materia Medica: Pharmacology: Therapeutics Prescription Writing For Students and Practitioners", by Walter A. Bastedo. Also available from Amazon: Materia Medica: Pharmacology: Therapeutics: Prescription Writing for Students and Practitioners.
Scarlet red is a name given to several different dye-stuffs, but that recommended for medicinal use is toluol-azotoluol-azobeta-naphthol. It is known as "Scarlet R," and is marketed in powder form and in 8 per cent. ointment. From the many published reports it would seem to have a marked power to stimulate the growth of epithelium over sluggish wounds and ulcers. Bullock and Rohdenburg consider it a chemical irritant of slow absorbability and low toxicity. Davis, of Johns Hopkins (1911, 1912), records very rapid covering of the surface of sluggish sores with epithelium having the macroscopic and microscopic appearances of normal skin. On the injection into dogs and rabbits of a 1 per cent. solution in oil he found it non-irritating and non-toxic, though it was disseminated through the body and stained the fatty tissues. In man he gave it by mouth, amounts of 32 grams, 63.3 grams, and 66.5 grams in about four weeks producing no symptoms, and being apparently unabsorbed, as they did not stain the fat of the body. He therefore recommends its use in gastric ulcer.
Hinman recommends a 10 per cent. solution in oil for laryngeal tuberculosis.
Gurbski reported poisoning in a child, and Lyle, in a woman. Both followed application to extensive burns, and the symptoms were headache, dizziness and faintness, followed by nausea, violent vomiting, abdominal cramps, and pain on urination. There was some fever, and albuminuria without casts.
Dimazon ointment is a modification that does not stain or irritate.