This section is from the book "Materia Medica Pharmacy, Pharmacology And Therapeutics", by W. Hale White. Also available from Amazon: Materia Medica Pharmacy, Pharmacology And Therapeutics..
(Not official). - C6H15No3=136.74. An alkaloid obtained from Amanita Muscaria, Fly Fungus.
Russia and Northern Europe.
A liquid of the consistence of syrup, without odor or taste.
Dose, 1/8 to 2 m.; .008 to .12 c.c.
Muscarine in its action somewhat resembles Calabar bean, and it is antagonistic to atropine. It produces free salivation, abundant perspiration, diminution of the force and frequency of the pulse, dyspnoea, paralysis and finally death. The pupil is contracted; dilating, however, before death. The cardiac diastole is prolonged, due to action upon the inhibitory nerves. The muscles of the intestines and bladder are markedly contracted. The abdominal secretions are increased. Although it has been but little used in medicine, it is likely to be useful in intestinal torpor, duodenal catarrh, and in inflammatory effusions and exudations. As it produces contraction of pulmonary capillaries, it is indicated in pulmonary haemorrhage and incipient pulmonary congestion.