This section is from the book "Materia Medica Pharmacy, Pharmacology And Therapeutics", by W. Hale White. Also available from Amazon: Materia Medica Pharmacy, Pharmacology And Therapeutics..
Concentrated Sulphuric Acid is allowed to act on Naphtalin, whereby B-Naphtalin Sulphonic Acid is formed (C10H7Hso3). This acid is dissolved in water, saturated with Milk of Lime, and the resulting Calcium Salt separated by crystallization. The crystals are re-dissolved in water and decomposed by Sodium Carbonate, yielding Sodium Naphtalin-Sulphonate (C10H7So3na). The Sodium Salt is next added to fused Sodium Hydroxide and Sodium-Naphtol C10H7ONa, and Sodium Sulphite NaSo3 is formed. The former is treated with Hydrochloric Acid and Naphtol is obtained, which is purified by sublimation and re-crystallization from hot water.
Colorless, or pale buff-colored, shining, crystalline laminae, or a white, or yellowish-white, crystalline powder, having a faint, phenol-like odor, and a sharp and pungent but not persistent taste. Solubility. - In about 1000 parts of water, and in 0.75 part of Alcohol; very soluble in Ether, Chloroform or solutions of caustic alkalies.
Dose, 1 to 20 gr.; .06 to 1.20 gm.
Naphtol was introduced as an antiseptic, at first in dermato-logical practice as a 10 per cent. ointment, in scabies, ringworm and psoriasis; it is, however, irritating in eczema. It is a remedy of great value in obtaining intestinal antisepsis, bacteriological investigations showing that it destroys certain micro-organisms in situ when administered to the extent of 40 gr.; 2.70 gm. per day. As it is irritating to the stomach it can be administered in keratin-coated pills. It is useful for cases of dilated stomach.