Sulphate of Copper. CuO,SO3 +5HO. Blue-stone. Blue Vitriol. A compound of Oxide of Copper 32, Sulphuric Acid 32, Water 36, in 100 parts; or 1 Eq. Oxide of Copper = 40, + 1 Sulphuric Acid = 40, + 5 Water = 45 = 125, Eq. Wt.
Med. Prop. and Action. Tonic and astringent, in dos3S of gr. 1/4 - gr. ij. In small doses it produces no sensible effect on the system; but under its continued use, the secretions diminish, the appetite increases, the pulse becomes stronger and fuller, and it acts as a general tonic and astringent. It also acts as a stimulant and tonic on the nervous system. In doses of gr. iij. - iv. - xij., it proves emetic, and without causing much depression of the system. In larger doses it is a powerful irritant poison. Externally it is applied in substance, to destroy unhealthy and excessive granulations, and as a styptic to bleeding surfaces. In solution (gr. j. - x. ad Aq. fl. oz. j.) it is used as a col-lyrium, wash, &c.
Dose, as a tonic and astringent, gr. 1/4 - gr. ij.; as an emetic, gr. iij. - gr. xij.
In Chronic Dysentery and Diarrhoea, a combination of Sulphate of Copper and Opium proves highly serviceable. Amongst others, Dr. J. Brown speaks favourably of it; and Mr. Raleigh records many cases which recovered under the use of the following formula: - Cupri Sulph. gr. 1/4 - 1/2, Pulv. Opii gr. 1/2, M. ft. pulv. ter in die sumend. I have seen much benefit from this formula, substituting gr. v. of Dover's Powder for the Opium, as advised by Mr. Raleigh. In the obstinate Diarrhoea of Phthisis, Dr. Watson* states that it often is effectual, in doses of gr. 1/4, combined with gr. 1/4 of Opium. It occasionally causes griping. In the Chronic Diarrhoea of Infants, Dr. Pereirat states that he has often employed it with the most excellent effects, in doses of 1/12 of a grain.
* Dublin Quart. Journ., Aug. 1850. Cyc. Pract. Med., vol. 1. p. 661.
Trans. of Med. Society of Calcutta, vol. vii. p. 66.
Dr. Ure. after remarking that it checks excessive mucous secretion from the lining membrane of the bronchial tubes and cells, states that Hoffman first employed it instead of Calomel in Croup. During the prevalence of an epidemic Croup, he gave it in cases of bronchitis and tracheitis, in doses of gr. 1/4 - 1/8, according to the age of the child, every two hours. If laryngitis were present, he ordered it in doses of gr. iij. - iv. (after depletion), to excite vomiting; and followed it up with the small doses, every quarter or half hour. It has since been employed by De Serto, Hufeland, Droste, and others; and, in the majority of instances, with marked success. Zimmerman§ also relates cases successfully treated with it. It should not interfere with the external use of leeches (if local depletion be indicated) hot-water fomentations, &c.