Since the publication of Pontaneille's success with Prussic Acid in this disease in 1817, many writers, particularly Granville, Thompson, Taylor, and Caspari, have advocated its employment. Of 100 cases treated by Dr. Macleod,|| 88 recovered under its use; 12 were unrelieved; and, of the latter class, 3 died. Dr. H. Roe¶ asserts that Prussic Acid will, if exhibited as soon as the whoop is first heard, effect a cure in every case of simple Pertussis. Mr. Hood** also speaks highly of its efficacy. Dr. C. B. Williams, however, justly observes, that its administration requires great caution, especially in young children; for its sedative influence affects the heart, as well as the muscles and nerves of respiration, and the circulation of very young subjects, if suddenly depressed, does not readily recover its power. There are other remedies as effectual, and more safe.

* Trans, of Louison Phthisis, p.376.

Cyc. Pract. Med., vol. iii.

Op. cit., p. 59.

§ Cyc. Pract. Med., vol. i.

|| Lond Med. and Phys. Journ., No. xlvi. p. 361.

¶ On Hooping-Cough, chap. vii.

** On Diseases of Children, Lond 1845.

Lib. of Med., vol. iii. p. 99.

1538. In Croup, Scheele's Acid Is Recommended By Mr

Hood* in doses of gutt. ij. combined with Soda, Opium, &c, to be given after the exhibition of an emetic. The employment of so powerful a sedative in young children is of very doubtful propriety. In Laryngismus Stridulus, however, it has been given by Dr. Reid with advantage. He prescribes the following formula: -1538 In Croup Scheele s Acid Is Recommended By Mr 139 Acid. Hydrocyanic. ev., Sp. Amnion. Fetid. f3ss., T. Hyoscyami ex., Syr. Aurant. fss., Sp. Anisi f3j., Aquae fj., M. Dose, a tea-spoonful, thrice daily.

1539. Diseases Of The Abdominal Viscera

In Dyspepsia, Cardi-algia, Gastrodynia, and sub-acute Gastritis, Prussic Acid has been given with marked benefit by Drs. Granville,% A. T. Thompson,§ Elliotson,|| Macleod.¶ and others. In doses of eiij. - v., combined with the Infusion of Calumba, it appears to possess remarkable power in allaying morbid irritability of the stomach, and of inducing a slower, and consequently a more healthy secretion of gastric juice. Speaking of its use in Gastrodynia, Dr. Watson** states that he has seen more rapid and decided relief afforded by Prussic Acid than by anything else, and that the cure so wrought is often permanent In Visceral Neuralgia, more particularly in Gastralgia and Enteralgia, Dr. Copland states that he has found it successful in some cases in which Colchicum produced remarkable depression. It may be given with Camphor, Ammonia, &c.

1540. Vomiting, arising from many morbid conditions, appears to be much relieved by the exhibition of Prussic Acid. Excepting in strictly inflammatory states, Dr. Lonsdale considers it highly useful, and ranks it next to Creasote in efficacy. It may be advantageously given in an effervescing draught. In Pyrosis, it also proves very serviceable. Its efficacy is increased by being conjoined with White Bismuth. Hypochondriasis, originating in derangement of the stomach, or kept up by a morbid state of the chylopoietic viscera, may be advantageously treated by this medicine. (Lonsdale.) In Dysentery, it was recommended by Dr. Thompson, and it was found very serviceable in two or three cases by Dr. Lonsdale.

1541. Skin Diseases, attended with much irritation, are often benefited by the local application of lotions containing Prussic Acid. Such lotions may be composed of from ex, to fl. drm. j. of dilute Hydrocyanic Acid to fl. oz. j. of Water or Glycerine. When a solution of the latter strength is used, it must not be

* Op. cit.

On Infantile Laryngismus, 8vo. 1849.

Op. cit, p. 366. § Cyc. Pract. Med., vol. iii. p. 725.

|| Cases Illustrative of the Efficacy of Hydrocyanic Acid, Lond. 1820.

¶ Lond. Med. and Phys. Journ., No. lix.

** Lectures, vol. ii. p. 446.

Dict. Pract. Med., vol. ii. p. 893.

applied over a very large surface, and the patient must be warned not to use it too freely. Caspari* recommends the diluted acid in Erysipelas. According to the experience of Dr. Thompson. it may be used as a lotion in three species of Lichen (particularly in Lichen Tropicus, or Prickly Heat); in Prurigo, to allay the vexatious itching; and in Lepra, where the skin is very irritable. In Impetigo, where there is much vesication, and ointments are too irritating, the following lotion was found highly serviceable: - ℞ Acid. Hydrocyan. f3iv., Aq. Dest. fviij., Alcohol f3iv., Plumb. Acet. gr. xvij., M. Ecthyma, Eczema, and Acne seemed also much benefited. (Lonsdale.) In Cancer, it has been advised as an external application to allay excessive pain, but the practice is fraught with danger, as, if it is applied to a large ulcerated surface, the acid may become absorbed into the system, and produce poisonous effects.