1. During the exhibition of Iodine give a light animal diet, carefully avoiding all articles containing much starchy matter, as this, by combining with the Iodine, renders it comparatively inert.

2. Enjoin exercise in the open air; close, dark, ill-ventilated rooms retard the action of the remedy.

3. Give the medicine an hour or two before a meal; if given on an empty stomach, it is liable to give rise to gastric irritation.

* Med. Chir. Rev.. July 1856. Treatise on the Nature, &c, of Scrofula.

Bull, de Therap., vol. xxxv. § Lancet, Sept. 5, 1863.

4. Employ an aqueous solution recently prepared, in preference to a strong alcoholic solution, such as the simple Tincture of the Edinburgh Pharm., which undergoes changes by long keeping. The Tincture of the Brit. Pharm. is a better preparation for internal use.

5. If it create irritation, diminish the dose and combine it with small doses of Henbane or Opium.

6. Be Careful To Regulate The Bowels

7. Up to a certain point, patients often visibly improve under the use of Iodine; there then occurs an arrest of benefit, and the disease remains stationary, or even begins to retrograde. Under these circumstances, discontinue the medicine for a week or two, and then resume it.

8. Dr

Rodet, of Lyons, from numerous observations, concludes that Iodine will rarely produce any ill effects, if given only in those cases which evidently call for its employment; that it acts much more favourably, if the patient has not already been subjected to other remedial measures; and that, where Mercury has been previously taken, Iodic ptyalism is likely to occur.

9. When syringes are to be employed, they should be of glass; when baths, the vessels containing the liquid should be of wood, marble, or glass. Metal vessels of all kinds should be avoided.

10. The recent stains of Iodine may be effectually removed by a little milk, alcohol, or diluted Liquor PotasssAe.

1576. Therapeutic Uses

Scrofula. This term embraces so large a number of affections, many of which require a peculiar mode of treatment, that it will be more convenient to consider each separately; premising, however, that they are all essentially the same disease, dependent upon the same cause, viz. tubercle, and are all, more or less, benefited by the same remedy, Iodine.

1577 Enlarged Lymphatic Glands. The glands of the neck and mamma are those most subject to scrofulous enlargement, at least in the external system, to which we are at present directing our attention. In these cases, the Ioduretted ointment externally, and the mineral water (ut supra) internally, offer one of the best chances of obtaining resolution. The ointment should not be applied oftener than once a day, for fear of producing inflammatory action of the tumour, rather than local excitement of the absorbents. The solution (ut supra) may be substituted where there is much tenderness of the skin. When suppuration has taken place, the solution, applied with a camel's-hair brush, is to be preferred, and it should be persevered in until the abscess is about to break, as such a proceeding tends much to circumscribe the limits of the suppuration. (Lugol.)

1578. In Scrofulotis Abscesses, the same general principles should guide us, as in the case of enlarged lymphatic glands. After the matter has been evacuated, Lugol proposes to inject a solution of Iodine (No. 2). By this means, it is stated that a gradual obliteration of the cavity of the abscess may be obtained. It is only applicable to abscesses of medium size; it would be neither safe nor advisable when they are of large extent.

1579. In Scrofulous Ulcers, the external and internal use of Iodine is of great service. Lugol observes, that it is not exaggeration to say that Iodine changes the appearance of scrofulous ulcers, sometimes more quickly than Mercury modifies those of a

syphilitic character. The ointment (No. 5) is generally preferable at first, the solution being more applicable to ulcers of long standing. It should, at the same time, be given internally and Ioduretted baths employed. M. Lemasson* relates eight cases successfully treated with Iodine combined with Opium; he justly observes, a fact I have often noticed, that in cases of scrofulous ulceration, the union of Opium with Iodine imparts to the latter a power which it does not possess singly. He advises the subjoined formula: -1576 Therapeutic Uses 141 Iod. gr. xv., Potas. Iod. j., T. Opii f3ij., Ung. 3ij., M.

1580. Unsightly Cicatrices, the result of Scrofulous Ulcers, may in a great measure, be prevented by occasionally touching the exuberant granulations with Caustic Iodine (No. 4); and in those cases where cicatrices have formed, much benefit will be derived from the same appucation, or of the Iodine ointment.

1681. In Scrofulous Diseases of the Bones, Joints, &c, and in Caries, Iodine appears to have been signally successful in the hands of Lugol, but it has been found less efficacious than in other forms of Scrofula, in the experience of Ranking, Baude-locque, and the majority of practitioners. Lugol directs it to be employed externally and internally; frictions with Iodine ointments to be made around the whole surface of the diseased joints; and, in cases of vertebral disease, on the loins. Iodine injections (No. 2) are advised by him, when fistulous canals are formed in the neighbourhood of diseased joints. The last practice is not unattended with danger, as it occasionally causes intense inflammation and sloughing of the soft parts. In disease of the hip-joint, Lugol recommends motion of the limb, and exercise in the open air. Leeches, setons, and issues, he strongly condemns.

1582. In Scrofulous Coryza, more benefit will be derived from the internal than the local use of Iodine. Perseverance in the aqueous solution (No. 1), with strict attention to the bowels, will be sufficient to effect a cure in the majority of cases.