Narcotine. C46H25NO14. Anarcotine (Beng. Ph.), a solid, white, inodorous, insipid, neutral, crystal-lizable principle, obtained from Opium. Insoluble in Water and alkalies; soluble in Alcohol, Ether, and Acids. With the latter it forms salts.

Med. Prop. and Action. Tonic, febrifuge, anti-periodic, and diaphoretic. It is entirely devoid of all narcotic properties. Dr. Garrod states that he has given it as a tonic and anti-periodic in half -drachm doses, without the production of any narcotic symptoms.

Dose, as a tonic, gr. j. - gr. iij. thrice daily; as a febrifuge and anti-periodic, gr. iij. - gr. v., or more. In doses of gr. xx. it has a diaphoretic action.

1870. Therapeutic Uses

Intermittent Fevers. Dr. O'shaugh-nessy states, that his experiments, repeated by many medical officers in all parts of India, have led to the conclusion, that Narcotine is, after Quinine, the most powerful febrifuge we possess. In doses of gr. iij. - v., dissolved in water, and acidulated by Hydrochloric or Sulphuric Acid, repeated thrice daily, it will prevent the return of ague in all ordinary cases. It has frequently succeeded when Quinine has previously failed. In Ague complicated with Dysentery, Narcotine is stated to be decidedly superior to Quinine, as it does not aggravate the local inflammation; but, on the contrary, seems to allay the pain and tenesmus. Dr. O'shaughnessy adduces the testimony of many medical officers in its favour. Its value as an anti-periodic is strongly advocated also by Dr. Gardeu,§ of the Bengal Medical Service, who considers the only objection to it is its tendency to produce constipation, to obviate winch purgatives are necessary.

1871. In Remittent Fever, Dr

O'shaughnessy || considers its powers not so well established, and recommends the employment of Quinine, unless the latter is either not available, or produces intolerable head symptoms, under which circumstances Narcotine may be boldly had recourse to.

1872. In Debility after Fevers, &c., Narcotine is a valuable tonic in doses of gr. j. thrice daily. Dr. O'shaughnessy states that he found it especially valuable in the convalescence from parturition, and in the debility which so often follows nursing in India.

* Bull de Therap., vol. xxxvi. 1849.

Essentials of Mat. Med. and Therap., p. 161.

Beng. Pharm., p. 261. § Lancet, Jan. 11, 1862. || Op. cit.