Pipeline. A crystalline nitrogenized feeble base found in Piper Nigrum, Piper Longum, and probably in other plants of the same order. Chem. Form. C34H19NO6.

Med. Prop. and Action. Febrifuge (?) and tonic. Dose, gr. vj. - x., twice or thrice daily.

2087. Therapeutic Uses

In Intermittent Fevers, Piperine has been employed with varying success. Amongst those who speak highly of its efficacy is Dr. Hartle, * of Trinidad, who states that, in the intermittents of that island, he found Piperine eradicate the disease when Quinine had failed, although the latter had been given in ten-grain doses, frequently repeated. He states that, in all cases of long standing (many of them complicated with enlargement of the liver and spleen), he began as soon as the sweating stage was established, by giving gr. iij. of Piperine every hour, until gr. xviij. had been taken; and, on the following day, when the intermission was complete, he gave the same quantity every three hours. In every case, he states, it succeeded in checking the paroxysm, and, as soon as this was accomplished, he gave the following pills: -2087 Therapeutic Uses 169 Pil. Hydrarg. gr. j., PiperinAe, Quinae Sulph. aa gr. ij., M. ft. pil. ter in die. In other cases he employed it without combining it with Quinine, and with decidedly beneficial effects. He recommends gr. xxxvj. to be given in twenty-four hours; and, though powerfully carminative, stimulating, and febrifuge, he never saw it affect the sensorium in any degree. Dr. Blom also bears witness to its efficacy, and states that he prefers it to either Quinine or Sali-cine in persons of phlegmatic temperaments, in whom a sluggish circulation and feeble digestion are observed. In the intermittents of Italy, it was successfully employed by Meli, Gordini, and others. On the other hand, Soubeiran§ found it fail, and O'shaughnessy|| states, that in no one instance has he found it of the least utility, although it was given in all doses, from one to thirty grains. These differences may be partially explained, perhaps, by the different degrees of purity of the remedy: if impure, and combined with a portion of the resin, its activity appears to be increased.