Acetate of Lead, called also the Proto-acetate, the Super-acetate, or Sugar of Lead. PbO, C4H3O3 + 3 HO. Comp. Oxide of Lead, 58.95, Acetic Acid 26.84, Water 14.21, in 100 parts; or 1 Eq. Oxide of Lead = 112, + 1 Acetic Acid = 51, + 3 Water (3 + 9) = 27 = 190, Eq. Wt.
Med. Prop. and Action. Internally, it is astringent and sedative; diminishing the secretions, and reducing the activity of the capillary system (see Phys. Effects, ante). Externally, in solution (gr. xxx. - gr. lx. ad Aq. fl. oz. vj.), it is used as a lotion. As a collyrium, it should not be employed when ulcers of the cornea exist, as it is apt to cause a permanent white cicatrix.
Offtc. Prep. Pilula Plumbi cum Opio (Acetate of Lead in fine powder grs. xxxvj.; finely-powdered Opium grs. vj.; Confection of Roses grs. vj.). Eight grains of the mass contain 1 gr. of Opium. Dose, gr. iv. - gr. viij.
Dose of Acetate of Lead, gr. 1/2 - gr. v.
on its Use. 1. In order to prevent the Acetate being converted into a carbonate, it is advisable to combine its use with dilute Acetic Acid, which can be taken in the form of draught, after each dose of the Acetate.
It is usually combined with Opium, an unchemical but efficacious formula. Common water should never be used as a vehicle.
It may be often safely and beneficially administered with Opium after depletion. Its action is then rather that of a sedative than of an astringent.
* Edin. Med. Surg. Journ., July 1, 1841.
4. The Acid infusion of Roses, Sulphuric Acid, all the sulphates, as of Magnesia or Alum, as well as the phosphates and carbonates, should be prohibited during its use, as they interfere with its operation.
Burton* observed this in one case after giving five doses of gr. v. each), or if there occur gripings, tightness of the chest, or burning of the stomachy it should be discontinued. Large doses, however, may be given, particularly if conjoined with the use of Acetic Acid, without these effects being observed.
6. Lotions containing this salt are unadvisable in ulceration of the cornea, as they leave indelible opaque cicatrices.
Incompatibles. Mineral and Vegetable Acids, excepting the Acetic; Alkalies; hard Water; Strychnine; all vegetable infusions containing Gum; Liq. Amnion. Acet.
In Aneurism of the Aorta, the Acetate of Lead, as an internal remedy, was first adopted by Dupuytren. who successfully employed it in three cases. After a small bleeding, he administered a pill containing Plumb. Acet. gr. j. twice a day, and this was gradually increased, until gr. vj. were taken in twenty-four hours. In one case the swelling sensibly diminished in three weeks; and in six weeks the patient left the hospital wonderfully relieved. Other cases successfully treated are recorded by Dusol and Legroux. Dr. Hope § also confirms the views of Dupuytren as to the value of the Acetate in these cases. He advises gr. ss. of the Acetate to be combined with gr. ss. of Opium, in the form of pill, to be repeated three or four times a day. Any gastric irritation may be removed by Castor Oil, diluents, &c. This treatment, however, must in most cases be considered only as an auxiliary to the important items of diet and regimen. The internal use of dilute Acetic Acid should be conjoined.