Bromide of Potassium. KBr. Hydrobromate of Potash. Comp. 1 Eq. Bromine = 80 + Potassium = 39 = 119, Eq. Wt.; or Bromine 67.22, and Potassium 32.78, in 100 parts.

Med. Prop. and Action. Stimulant, alterative, anaphrodisiac, and deob-struent. Its action is similar to, but milder than that of Iodide of Potassium. When administered internally, it is absorbed into the system, and Las been detected in the blood and in the urine. " Its action," observes Dr. Glover, "is exceedingly obscure; it acts in most cases as a diuretic, occasionally produces diarrhoea, and possesses somewhat of that action on the secretions and excretions, which renders the corresponding iodide so powerful a deob-struent." Dr. Garrod, however, states that he has not found it exert any marked action on the kidneys or skin. In large doses, it may give rise to drowsiness and headache; and in still larger, it produces loss of power in the lower extremities, and exerts a remarkable influence over the sexual function, which it diminishes in a remarkable degree. As an anaphrodisiac its powers are unequivocal. It is perhaps one of the most powerful agents of that class. It also exerts an anaesthetic influence over the mucous membranes generally, but especially over those of the pharynx and larynx, - a circumstance which has been taken advantage of in preparing patients for laryngoscopic examinations and operations. As an instance of its power in producing anaesthesia of a mucous surface, M. Riemslaghf cites the case of a man whose eyes had been injured by the discharge of a pistol. Under the use of the Bromide, the insensibility of the conjunctiva became so perfect that the membrane was partially removed, and particles of powder, &c, extracted from the sclerotic itself, without the least manifestation of pain. To obtain this effect, it requires to be given in large doses, gr. xv. - xxx., in two or three doses, at intervals of an hour. Some persons whilst taking it experience a peculiar dryness of the throat and neighbouring parts. According to Dr. Garrod, it does not produce the symptoms of the condition known as " Iodism." Externally, it is applied in the form of ointment (gr. xx. - gr. cxx., ad Adipis oz. j.).

Dose, gr. iij. - gr. xv., or even more.

Incompatible*. Acids, and the salts of most metals and earths.

2261. Therapeutic Uses

In Scrofula, the Bromide, employed internally and externally, proved successful in the hands of MM. Bonnet,|| Magendie.¶ Pourchg,** and others. Dr. Glover relates several cases treated by it; in some, particularly in one case of scrofulous ulcer of the leg (No. 7), it was productive of great benefit; but in others the results were unsatisfactory.

2262. In Enlargements Of The Spleen, Dr

R. Williams employed the Bromide successfully in four cases. He commenced with gr. j. thrice daily, and gradually increased the dose to gr. iv. He considers that in these cases it is possessed of unusual, if not specific, powers. In other hands, it has occasionally failed. In Enlargement of the Liver, it was also found serviceable.

* On Diseases of the Skin, 8vo. 1835.

Edin. Med. Surg. Journ., Oct. 1, 1842, p. 340.

Med. Times and Gaz., March 12, 1864.

§ Medical Circular, Oct. 15, 1869.

|| Bull. Gen. de Therap., July 1837. ¶ Formulary, 1835. ** Journ. de Chim. Med, iv. p. 594. Elements of Med., vol. i. p. 330.

2263. In Epilepsy, It Has Been Highly Spoken Of By Dr

C. B. Radcliffe, Dr. Ramskill,* Dr. H. Jackson, and others. In cases uncomplicated by loss of memory and other symptoms of serious cerebral affection, Dr. Radcliffe has found excellent results from the Bromide. In such cases it may be administered in doses of gr. x. - xx. three times a day. It seems to have the power of keeping the fits off for long periods - months, or even a year. But they return when the drug is given up. Its anaphrodisiac properties indicate it as a remedy for Epilepsy dependent on masturbation. It has been prescribed in Epilepsy following Diphtheria, by Dr. Ramskill.

2264. Besides the above, it has been employed in Amenorrha and Hypertrophy of the Ventricles, by Magendie; in Carbuncle, by Mr. Bennett; in Tinea Capitis, by Prieger; and in obstinate Dartrous Affections, and Malignant Ulcers, by Dr. Glover. In the Incontinence of Urine in Children, Dr. Hewsong tried the Bromide (gr. iiss. - iij. thrice daily) in sixty-three cases: of these nine were cured and four were benefited; the other fifty derived no benefit. In Gonorrha, M. Pviemslagh|| found the Bromide an effectual cure in doses of gr. xv. - xxx. taken in two or three doses at intervals of an hour. It effectually relieved the Chordee in these cases. In Hysterical Epilepsy, occurring at the menstrual periods, Sir C. Locock¶ successfully employed the Bromide in doses of gr. x. thrice daily. To be effectual it requires to be persevered in for some months. It acts in a marked manner in subduing generative excitement; and it may be given with advantage in Nymphomania, Priapism, and some forms of Spermatorrha, and in Menorrhagia depending on uterine and ovarian excitement. In Syphilitic Psoriasis and other Syphilitic Eruptions, Dr. Garrod** has substituted it for Iodide of Potassium with complete success.